人参皂苷Rg2对麻醉犬急性心源性休克血流动力学和氧代谢的影响

目的：观察人参皂苷Rg₂(ginsenoside Rg₂)对犬急性心源性休克血流动力学和氧代谢的影响。方法：结扎犬冠状动脉左前降支（LAD）复制心源性休克模型，观察人参皂苷Rg₂（2和1 mg•kg^-1)对麻醉犬血流动力学和氧代谢各项指标的作用。结果：人参皂苷Rg₂可升高平均血压（MBP）、左室内压(LVSP)、±dp/dt_max和心排出量(CO)，降低心肌耗氧指数、心肌氧摄取率。结论：人参皂苷Rg₂对犬急性心源性休克具有一定的治疗作用。

Effects of ginsenoside Rg2 on hemodynamics and oxygen metabolism in narco-canine with acute cardiogenic shock

Objective To investigate the effects of ginsenoside Rg 2 on hemodynamics and oxygen metabolism in narco-canine with acute cardiogenic shock. Methods Model of acute cardiogenic shock was made by ligating left anterior descending branch of coronary artery(LAD). Hemodynamics and oxygen metabolism in narco-canine were observed after administrated with 2 and 1 mg·kg -1 ginsenoside Rg 2. Results Ginsenoside Rg 2 increased mean blood pressure (MBP),left ventricular systolic pressure (LVSP),±dp/dt max,and cardiac output (CO), remarkably, and reduced the exponent of oxygen consuming of myocardium and the rate of oxygen intake of myocardium compared with control group. Conclusion Ginsenoside Rg 2 has therapeutical effect on acute cardiogenic shock in canine.