规范化治疗轻中度妊娠期甲状腺功能亢进患者的临床分析

目的探讨规范化治疗轻中度妊娠期甲状腺功能亢进患者的临床效果。方法 120例轻中度妊娠期甲状腺功能亢进患者随机分为对照组和观察组,观察组口服丙硫氧嘧啶片,对照组不使用药物治疗。观察两组甲状腺激素水平及妊娠结局。结果观察组TT_4、TT_3、TT_3、FT_4比对照组低,FSH比对照组高,有显著性差异(P<0.05)。观察组妊娠结局明显优于对照组,差异有统计学意义(P<0.05)。结论轻中度妊娠期甲状腺功能亢进会产生不良的妊娠结局,尽早使用丙硫氧嘧啶片(PTU)进行规范化治疗,有利于孕妇自身的健康以及妊娠结局,值得在临床推广。

Clinical Analysis of Patients with Mild-to-moderate Gestational Thyroid Hyperfunction Treated by Standardized Treatment

Objective To explore the clinical effects of patients with mild-to-moderate gestational thyroid hyperfunction treated by standardized treatment. Methods 120 cases of patients with mild-to-moderate gestational thyroid hyperfunction in our hospital were divided into treatment group and control group. Treatment group were given PTU and control group were given no drug for treatment. The thyroid hormone levels and pregnancy outcome were observed. Results The serum levels of TT4, TT3, FT3, and FT4 of treatment group were higher than that of control group, and FSH lower than control group, the differences were statistically significant（P〈0.05）. The pregnancy outcome of treatment group was better than that of control group, the difference was statistically significant（P〈0.05）. Conclusions Mild-to-moderate gestational thyroid function hyperfunction may lead to adverse pregnancy outcomes. Using PTU for a standardized treatment promote the health of pregnant women, and also improve pregnancy outcome, worth clinical application.