The effects of post-heparin plasma lipases on anti-Xa clotting activity |
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| Authors: | S P Williams T W Barrowcliffe |
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| Institution: | 1. Chemistry Section UK;2. Division of Blood Products, National Institute for Biological Standards and Control, Holly Hill, Hampstead, London NW3 6RB, U.K. |
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| Abstract: | The effects of hepatic triglyceride lipase (HTGL) and lipoprotein lipase (LPL) on the anti-Xa clotting activity of plasma were studied. LPL had no effect, but HTGL enhanced anti-Xa activity. This enhancement was shown to be due to a time-dependent action of HTGL on lipoproteins. These results could explain the increases in anti-Xa clotting activity previously observed after injection of heparin analogues, SSHA and SP54, which are potent releasers of lipase enzymes. |
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| Keywords: | Lipase Heparin Anticoagulant |
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