阻塞性睡眠呼吸暂停低通气综合征合并高血压患者不同血压分级与相关因素分析

目的 通过对阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)合并高血压患者血压变化情况的研究,探讨OSAHS与高血压的相关关系.方法 选取确诊的OSAHS合并高血压患者95例及单纯OSAHS患者95例.所有患者完成至少7 h的多导睡眠监测,同时测量患者的睡前血压,睡着血压,醒后即刻血压,分析不同的高血压分级与OSAHS相关指标之间的相关性.结果 不同分级的高血压睡眠呼吸暂停指数(AHI)之间有较大的差异.AHI与醒时即刻-睡着收缩压(SBP)差值,睡着睡前舒张压(DBP)差值无相关性(P>0.05),与睡着-睡前SBP差值及醒时即刻睡着DBP差值有相关性(P<0.05);夜间平均血氧饱和度、夜间最低血氧饱和度、睡前与睡着DBP差值、醒时即刻与睡着DBP差值与血压分级存在相关性(P<0.05),而醒时即刻与睡着SBP差值、睡前与睡着SBP差值、AHI、体质量指数、CT90与血压分级不存在相关性(P>0.05).结论 睡着-睡前DBP及醒时即刻-睡着血压的变化、夜间平均血氧饱和度、夜间最低血氧饱和度与OSAHS患者的血压分级相关(P<0.05).

Correlative study between related factors and different grades of hypertension with patients of obstructive sleep apnea-hypopnea syndrome and hypertension

Objective To study the correlation between obstructive sleep apnea-hypopnea syndrome (OSAHS) with hypertension by researching fluctuation of blood pressure about the patients of OSAHS complicated with hypertension. Methods The study enrolled 95 patients diagnosed OSAHS complicated with hypertension and 95 patients with OSAHS only and the correlation was evaluated. All patients had been monitored at least for 7 hours in the lab. And the indexes included blood pressure during sleeping and arousal,apnea hypopnea index(AHI),et al. The correlation between different grades of hypertension with related factors was studied. Results AHI index between the different grades of hypertension was significant. There was no correlation between AHI with the difference value of SBP before sleeping and sleeping, but was with the difference value of depth average night O2sat ,lowest night O2ast ,difference value of DBP before sleeping and sleeping and difference value of DBP arousal and sleeping correlates to the hypertension grade( P <0.05), but there was no correlation between difference value of DBP arousal and sleeping, difference value of DBP before sleeping and sleeping and difference values of SBP, AHI, BMI,CT90 with the hypertension grade ( P> 0.05). Conclusions There are correlation between different levels of hypertension with the difference value of DBP before sleeping and sleeping,arousal and sleeping,the average night O2sat,lowest night O2sat, ( P<0.05).