儿童紫癜性肾炎巨噬细胞移动抑制因子表达及意义

目的：探讨巨噬细胞移动抑制因子（MIF）在紫癜性肾炎（HSPN）患儿中的表达变化及意义。方法：应用免疫组织化学法检测不同程度病理损害HSPN组和对照组（薄基底膜病）肾组织标本中MIF的表达，并分析与24 h尿蛋白定量的相关关系。结果：对照组肾脏仅有微弱的MIF表达，HSPN组的MIF表达增加，且随病理分级的加重而增强。HSPN病理Ⅲ～Ⅳ级组、Ⅰ～Ⅱ级组的肾活检组织MIF阳性强度均较对照组显著增强（P<0.01）；Ⅲ～Ⅳ级组的肾活检组织MIF阳性强度较Ⅰ～Ⅱ级组显著增强（P<0.01）。在伴有新月体、炎性细胞浸润的肾组织中MIF表达增加明显。HSPN肾组织MIF表达与24 h尿蛋白定量具有显著相关性（P<0.01）。结论：MIF在介导HSPN肾损害中可能起着重要作用，其表达上调可作为反映HSPN肾病理损害程度的指标。［中国当代儿科杂志，2010，12（2）：120-122］

Renal expression of macrophage migration inhibitory factor in children with Henoch-Sch-nlein purpura nephritis

Objective To examine the expression of macrophage migration inhibitory factor (MIF) in renal tissues obtained from children with Henoch-SchOnlein purpura nephritis (HSPN).Methods The renal tissue samples were obtained from 11 children with different pathological grades of HSPN and 8 children with thin glomerular basement membrane disease (controls). The MIF expression was measured by immunohistochemistry. The correlation between MIF expression and 24 hrs urinary protein excretions was evaluated using a line...