| CD44v6在胆囊癌中的表达及其意义 |
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| 引用本文： | 周彦明,李玉民,曹农,杨伟林,周文策.CD44v6在胆囊癌中的表达及其意义[J].肝胆外科杂志,2002,10(3):183-184. |
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| 作者姓名： | 周彦明 李玉民 曹农 杨伟林 周文策 |
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| 作者单位： | 兰州医学院第一附属医院普外科,兰州,730000 |
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| 摘 要： | 目的探讨CD44v6与胆囊癌发生及胆囊癌恶性生物学行为的关系.方法应用免疫组织化学法研究CD44v6在29例胆囊癌、16例胆囊腺瘤及8例正常胆囊组织中的表达.结果 CD44v6在正常胆囊组强保未见表达,胆囊癌与胆囊腺瘤中的表达率分别为62.1%和19%,CD44v6的表达与胆囊癌淋巴结转移相关(P＜0.05),未分化及低分化胆囊癌CD44v6的表达率显著高于高分化胆囊癌(P＜0.05).结论 CD44v6参与胆囊癌的发生、发展.
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| 关 键 词： | 胆囊癌 CD44v6 生物学行为 |
| 文章编号： | 1006-4761(2002)03-0183-02 |
| 修稿时间： | 2001年10月10 |
EXPRESSION OF CD44v6 AND ITS SIGNIFICANCE IN GALLBLADDER CARCINOMA |
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| Zhou Yanming,Li Yumin,Cao Nong,et al..EXPRESSION OF CD44v6 AND ITS SIGNIFICANCE IN GALLBLADDER CARCINOMA[J].Journal of Hepatobiliary Surgery,2002,10(3):183-184. |
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| Authors: | Zhou Yanming Li Yumin Cao Nong |
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| Institution: | Zhou Yanming,Li Yumin,Cao Nong,et al. Department of General Surgery,The First Affiliated Hospital of Lanzhou Medical College,Lanzhou,730000 |
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| Abstract: | Objective To evaluate the expression of CD44 v6 in gallbladder carcinoma and its relation to the tumor oncogenesis and malignant biological behavior.Methods SABC immunohistochemistry was used to detect the expression of CD44 v6 in gallbladder carcioma and gallbladder adenoma as well as nomal gallbladder tissue.Results The CD44 v6 positive staining were not detected in nomal gallbladder tissue,the positive rates in gallbladder carcinoma and adenoma were 62.1% and 19%,respectively.The expression of CD44 v6 was related to tumor lymph node metastasis (P<0.05).The positive rates of CD44 v6 were significantly higher in cases of poorly or undifferentiation than that of well differention(P<0.05).Conclusion CD44 v6 is involved in the oncogenesis and development of gallbladder carcinoma. |
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| Keywords: | CD44v6 |
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