三物降压汤对高血压病患者血压及淋巴因子激活的杀伤细胞的影响

目的：研究三物降压汤对血压、淋巴因子激活的杀伤（ＬＡＫ）细胞的影响及其可能机制。方法：用随机、单盲、自身、组间平行对照法用三物降压汤对轻度高血压病患者（n＝３０）进行为期８周的治疗观察，并与开搏通治疗组（n＝３０）比较。分别检测治疗前后的血压、ＬＡＫ细胞的增殖与活性、ＬＡＫ细胞表达的超氧化物歧化酶（ＳＯＤ）样物质及其对自由基的清除能力，为进一步了解ＬＡＫ细胞与血压之间的关系，并观察了自发性高血压大鼠（ＳＨＲ）胸主动脉环对硝酸甘油和乙酰胆碱（Ａch）的舒张反应以及ＬＡＫ细胞与ＳＯＤ标准品对ＳＨＲ胸主动脉环对Ａch舒张反应的影响并与京都威斯特大鼠及经三物降压汤治疗后的ＳＨＲ比较。结果：三物降压汤在降血压同时，ＬＡＫ细胞增殖、活性、其所表达的ＳＯＤ及清除自由基效应均明显增加。结论：三物降压汤既能降血压又能调节免疫功能。

Effect of Sanwu Hypotensive Decoction on Blood Pressure and Lymphokine Activated Killer Cell in Patient of Primary Hypertension and Spontaneously Hypotensive Rats

Objective: To investigate the effect of Sanwu hypotensive decoction (SWHD) on blood pressure (BP) and lymphokine activated killer cell (LAK) and possible mechanism. Methods: Thirty mild hypertension patients were treated with SWHD for 8 weeks, the levels of BP, proliferative ability and activity of LAK cell, SOD like substance expressed by LAK cell and its radical scavenger ability before and after treatment were observed using randomized, single blinded, self control, paralled assay, and compared with other 30 patients treated with captopril for control. In an experimental study, the vasodilatory response of thoracic aortic ring to acetylcholine and nitroglycerine, and effect of LAK cell, standard reagent of SOD, SWHD on the response were observed and compared in spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKR). Results: After SWHD treatment, along with lowering of BP, the proliferative ability, activity SOD like substance expressed by LAK cell and its radical scavenger ability increased significantly. Conclusion: SWHD is not only an effective hypotensive agent, but also an immunoregulator