Detection and characterization of simian retroviruses homologous to human T-cell leukemia virus type I |
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Authors: | A Komuro T Watanabe I Miyoshi M Hayami H Tsujimoto M Seiki M Yoshida |
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Affiliation: | 1. Department of Animal Pathology, Institute of Medical Science, University of Tokyo, Tokyo, Japan;2. Department of Viral Oncology, Cancer Institute, Toshima-ku, Tokyo, Japan;3. Third Department of Internal Medicine, Kochi-Medical School, Kochi, Japan |
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Abstract: | Lymphoid cell lines were established from five different species of monkeys which were positive in antibodies cross-reactive with human T-cell leukemia virus type I (HTLV-I) and were shown to contain provirus sequences homologous to HTLV-I. Gene-specific probes of HTLV-I, gag, pol, env, pX, and LTR, hybridized efficiently with monkey DNAs from these cell lines under stringent conditions, indicating that the proviruses are very similar to HTLV-I along with whole viral genomes. However, the preliminary restriction mapping turned out the difference between simian retroviruses and HTLV-I and also among simian retroviruses. These findings suggest a common ancestor of simian and human retroviruses, but exclude the recent interspecies transmission between monkeys and humans. |
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Keywords: | Author to whom requests for reprints should be addressed. |
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