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DCs-based therapies: potential strategies in severe SARS-CoV-2 infection |
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| Authors: | Jian Han Jiazhi Sun Guixin Zhang Hailong Chen |
| Affiliation: | 1.General Surgery Department, The First Affiliated Hospital of Dalian Medical University, Dalian, China.;2.Institute of Integrative Medicine of Dalian Medical University, Dalian 116044, China.;3.Department of Pharmaceutical Sciences USF Health, Taneja College of Pharmacy University of South Florida, Tampa, FL, USA. |
| Abstract: | Pneumonia caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is spreading globally. There have been strenuous efforts to reveal the mechanisms that the host defends itself against invasion by this virus. The immune system could play a crucial role in virus infection. Dendritic cell as sentinel of the immune system plays an irreplaceable role. Dendritic cells-based therapeutic approach may be a potential strategy for SARS-CoV-2 infection. In this review, the characteristics of coronavirus are described briefly. We focus on the essential functions of dendritic cell in severe SARS-CoV-2 infection. Basis of treatment based dendritic cells to combat coronavirus infections is summarized. Finally, we propose that the combination of DCs based vaccine and other therapy is worth further study. |
| Keywords: | dendritic cells (DCs) vaccine Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection immunotherapy immune system response therapeutic vaccine |