Infliximab Was Found to Be Effective for Treating Immunosuppressive Drug-resistant Hepatitis due to Durvalumab |
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| Authors: | Koki Nakashima Yoshiki Demura Masahiro Oi Mio Tabata Toshihiko Tada Kohei Shiozaki Masaya Akai Tamotsu Ishizuka |
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| Affiliation: | 1.Department of Respiratory Medicine, Japanese Red Cross Fukui Hospital, Japan; 2.Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Japan |
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| Abstract: | A 69-year-old man with stage III lung squamous cell carcinoma developed immune-related hepatitis following treatment with durvalumab, and was given high-dose corticosteroids and immunosuppressive drugs (mycophenolate mofetil, azathioprine, tacrolimus) but without demonstrating any improvement. Two cycles of infliximab (5 mg/kg) were then administered and thereafter the hepatitis improved. At the time of writing (9 months after the initiation of first course of durvalumab), the patient is alive without either any hepatitis symptoms nor any lung cancer progression. Infliximab may be effective for treating non-small cell lung cancer (NSCLC) patients who develop immunosuppressive drug-resistant immune-related hepatitis caused by durvalumab. |
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| Keywords: | non-small-cell lung cancer immune checkpoint inhibitor durvalumab immune-related adverse event hepatitis infliximab |
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