| AGGF1在肿瘤中的作用及其调控机制 |
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| 引用本文： | 沈夏波,李岩,王伟. AGGF1在肿瘤中的作用及其调控机制[J]. 国际肿瘤学杂志, 2019, 46(3): 166-169 |
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| 作者姓名： | 沈夏波 李岩 王伟 |
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| 作者单位： | 安徽医科大学附属安徽省立医院肿瘤内科,合肥,230001;中国科学技术大学附属第一医院肿瘤内科,合肥,230001 |
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| 基金项目： | 国家自然科学基金(81201906);安徽省自然科学基金(1708085QH177). |
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| 摘 要： | 血管生成因子含G补缀和FHA域1(AGGF1)是近年来鉴定出来的血管生成因子,其在血管内皮细胞高度表达,可表现出与血管内皮生长因子一样的功能,能够促进新生血管生成。近年来研究发现,AGGF1在肝癌、白血病、胶质瘤和胃癌等多种肿瘤中呈高表达。基于其可参与调控肿瘤血管生成、DNA修复和细胞自噬等机制,高表达AGGF1的肿瘤容易产生耐药及发生转移,其患者的生存与预后较AGGF1低表达的患者更差。深入了解AGGF1影响肿瘤血管生成的作用及具体的分子机制,可为抗肿瘤血管生成的治疗提供新策略。
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| 关 键 词： | 肿瘤 新生血管化 病理性 DNA修复 自噬 AGGF1 |
Roles of AGGF1 in tumor and its regulatory mechanisms |
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| Shen Xiabo,Li Yan,Wang Wei. Roles of AGGF1 in tumor and its regulatory mechanisms[J]. Journal of International Oncology, 2019, 46(3): 166-169 |
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| Authors: | Shen Xiabo Li Yan Wang Wei |
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| Affiliation: | (Department of Medical Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China;Department of Medical Oncology, First Affiliated Hospital of University of Science and Techno-logy of China, Hefei 230001, China) |
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| Abstract: | Shen Xiabo;Li Yan;Wang Wei(Department of Medical Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China;Department of Medical Oncology, First Affiliated Hospital of University of Science and Techno-logy of China, Hefei 230001, China) |
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| Keywords: | Neoplasms Neovascularization, pathologic DNA repair Autophagy AGGF1 |
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