| 星点设计-效应面优化眼用银黄温敏凝胶的制备工艺 |
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| 引用本文： | 陈智,叶思勇. 星点设计-效应面优化眼用银黄温敏凝胶的制备工艺[J]. 国际中医中药杂志, 2019, 41(1): 67-71 |
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| 作者姓名： | 陈智 叶思勇 |
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| 作者单位： | 山东中医药大学药学院,济南,250355;济南市第二人民医院药剂科 250001 |
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| 基金项目： | 山东省自然科学基金(ZR2017LH070);山东省高等学校科技计划项目(J17KA245). |
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| 摘 要： | 目的研究眼用银黄温敏凝胶的制备工艺。方法以泊洛沙姆407、泊洛沙姆188用量为考察指标,以胶凝温度为考察指标,采用星点设计-效应面法筛选银黄温敏凝胶处方,并对其他辅料因素进行考察,确定眼用银黄温敏凝胶的最佳制备工艺。结果眼用银黄温敏凝胶最佳处方为:泊洛沙姆407用量20%,泊洛沙姆188用量1%,透明质酸用量0.1%,苯扎氯铵用量0.01%,乙二胺四乙酸用量0.02%。结论眼用银黄温敏凝胶制备工艺简单,稳定性好,相变温度适宜。
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| 关 键 词： | 凝胶剂(中药) 星点-设计响应面法 泊洛沙姆 剂型改进 |
Optimized the preparation process of thermo-sensitive Yinhuang ophthalimic gel by central composite design-response surface method |
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| Chen Zhi,Ye Siyong. Optimized the preparation process of thermo-sensitive Yinhuang ophthalimic gel by central composite design-response surface method[J]. International Journal of Traditional Chinese Medicine, 2019, 41(1): 67-71 |
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| Authors: | Chen Zhi Ye Siyong |
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| Affiliation: | (College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Pharmacy Department,the Second People's Hospital of Jinan,Jinan 250001,China) |
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| Abstract: | Chen Zhi;Ye Siyong(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Pharmacy Department,the Second People's Hospital of Jinan,Jinan 250001,China) |
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| Keywords: | Gels (TCD) Central composite design-response surface method Poloxamer Dosage forms improving |
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