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Adenovirus—Extracellular Protein Interactions and Their Impact on Innate Immune Responses by Human Mononuclear Phagocytes
Authors:Coraline Ch  neau,Eric J. Kremer
Affiliation:Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, CNRS (French National Centre for Scientific Research), 34090 Montpellier, France;
Abstract:The aim of this review is to highlight how, in a syngeneic system, human mononuclear phagocytes respond to environments containing human adenovirus (HAdV) and soluble extracellular proteins that influence their innate immune response. Soluble extracellular proteins, including immunoglobulins, blood clotting factors, proteins of the complement system, and/or antimicrobial peptides (AMPs) can exert direct effects by binding to a virus capsid that modifies interactions with pattern recognition receptors and downstream signaling. In addition, the presence, generation, or secretion of extracellular proteins can indirectly influence the response to HAdVs via the activation and recruitment of cells at the site of infection.
Keywords:adenovirus   innate immunity   antibody   antimicrobial peptide   coagulation factor   complement   dendritic cell   host defense peptide   alarmin
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