中效胰岛素在糖尿病酮症治疗中的可用性探讨

目的 :探讨中效胰岛素 (NPH)用于糖尿病酮症 (DK)及其轻中度酸中毒 (DKA)的有效性和优越性。方法 :分直接NPH治疗法和NPH参与治疗法两种形式。对不同程度DK病人进行治疗的有效性观察 ;并设回顾性调查病例为对照组 ,分别从治疗的有效性、KET反跳率、低血糖发生率、需住院率以及住院时间等方面进行考察。结果 :NPH直接治疗轻度DK组 2 4h、36h酮体消失率分别为 5 5 6 %和 10 0 % ;36h血糖降至 10mmol/L以下达 6 7 8% ;对DKA的NPH参与治疗显示 ,KET反跳率、低血糖发生率、需住院率以及平均住院时间均有相当程度的降低。结论 :NPH治疗DK和DKA有效并有其相对的优越性

Applied Study of NPH in the Treatment of Disbetic Ketosis

Objective: To probe the efficiency and superiority of NPH in the treatment of diabetic ketosis(DK) and ketoacidosis(DKA). Methods: The therapy was divided into NPH direct treatment method and NPH enlist method. The efficieney was observed in the patients with different degree of DK. The cases surveyed retrospectively was taken as control group. The observed items efficiency of treatment ,bounce rate of KET, incidency of hypoglycemia,rate of hospitalization and time of hospitalization . Results: Under the NPH direct treatment,in low-grade DK group,the rates of ketonic acid disappear in 24h and 36h were 55.6% and 100%; in 67.8% patients the blood sugar was reduced below 10 mmol /L .For the NPH enlist DKA group, the bounce rate of KET ,incidence of hypoglycemia,rate of hospitalization and average time of hospitalization all had different grade of reduction. Conclusion: NPH is effective in the treatment of DK and DKA and has superiority.