中药PT液对衰老小鼠谷胱甘肽、免疫功能及元素的影响

目的：观察PT液对脑老化指标变化。方法：用D－半乳糖制造小鼠衰老模型同时服用PT液观察脑组织中GSH、总抗氧化能力、MDA及Ca^2 ,Mg^2 ,Zn^2 ,Cu^2 ,Fe^2 ,胸腺、乙宫重量变化。结果：PT液能增加脑组织中GSH含量、降低MDA生成 （P＜0．05），脑组织中C^2 含量下降、Zn/Cu比值上升（P＜0．01），小鼠胸腺重量增加近2－3倍（P＜0．01），红细胞、脑组织蛋白量也随着药浓增加而增加，子宫重量恢复正常。结论：PT提取液能增加脑组织抗氧化能力，通过降低Ca^2 ,Zn/Cu比值，提高机体免疫功能及恢复性膛水平而产生抗衰老作用。

The influence of PT in traditional Chinese medicine to GSH, immunity function and element in aged little mouse

OBJECTIVE:To observe the influence of PT extract to brain aging index. METHOD:Use D- half production of milk sugar little mouse aged model at the same time take PT liquid observation brain organization in GSH fight oxidize ability, MDA andalways Ca 2+ , Mg 2+, Zn 2+, Mn 2+ , Cu 2+, Fe 2+ ion , chest gland , womb weight change. RESULTS:PT extract can increase brain tissue in GSH content and reduce the production of MDA ( P < 0.05), the Ca 2+ content brain is reduced, the ratio of Zn/Cu increases ( P < 0.01), mouse chest gland weight increases 2-3 near times( P < 0.01). The protein contentin red blood cell and brain increase as drug concentration womb weight returns to normal.CONCLUSION:PT extract will increase anti-oxidize ability of brain by reducing Ca 2+ concentration and the ratio of Zn/Cu, improving organism immunity function and recovering the level of sexual gland.