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| 自制和国外的6-OH-BTA-0放射性核素标记效果的比较 | |
| 引用本文： | 姚志文,丁正同,王坚,胡名扬,薛方平,刘平,管一晖,许震生,蒋雨平. 自制和国外的6-OH-BTA-0放射性核素标记效果的比较[J]. 中国临床神经科学, 2008, 16(2): 126-129 |
| 作者姓名： | 姚志文 丁正同 王坚 胡名扬 薛方平 刘平 管一晖 许震生 蒋雨平 |
| 作者单位： | 1. 复旦大学附属华山医院,神经科,200040 2. 上海医学生命科学研究中心有限公司,200032 3. 复旦大学附属华山医院,PET中心,200040 |
| 基金项目： | 上海市经济委员会资助(编号:05JYYY-49) |
| 摘 要： | 目的：观察放射性核素标记的不同来源的6-OH-BTA-0，比较制备的阿尔茨海默病（AD）PET显像剂[^11C]6-OH-BTA-1的效果。方法：分别使用两种来源的6-OH-BTA-0，以同样的反应条件，通过^11C-Triflate-CH3行放射性核素^11C标记成[^11C]6-OH-BTA-1，应用C18cartridge柱提纯产品。结果：两种不同来源的6-OH-BTA-0，标记出产品[^11C]6-OH-BTA-1的效果没有明显差异。按照加速器生产925MBq“c—Triflate—CH3计算，未校正“c衰变的情况下，无色澄清[^11C]6-OH-BTA-1注射液的产率均在36％-44％，放化纯92％-93％。结论：自制的6-OH-BTA-0可以在ADPET显像剂[^11C]6-OH-BTA-1研究中使用。 |
| 关 键 词： | β-淀粉样蛋白 正电子发射断层扫描 碳放射性核素 6-OH-BTA-0 |
| 文章编号： | 1008-0678(2008)02-0126-04 |
| 修稿时间： | 2007-12-22 |
Comparison of Differently Acquired 6-OH-BTA-0 |
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| YAO Zhi-Wen,DING Zheng-Tong,WANG Jian,HU Ming-Yang,XUE Fang-Ping,LIU Ping,GUAN Yi-Hui,XU Zhen-Sheng,JIANG Yu-Ping. Comparison of Differently Acquired 6-OH-BTA-0[J]. Chinese Journal of Clinical Neurosciences, 2008, 16(2): 126-129 | |
| Authors: | YAO Zhi-Wen DING Zheng-Tong WANG Jian HU Ming-Yang XUE Fang-Ping LIU Ping GUAN Yi-Hui XU Zhen-Sheng JIANG Yu-Ping |
| Affiliation: | YAO Zhi-Wen, DING Zheng-Tong, WANG Jian, HU Ming-Yang, XUE Fang-Ping, LIU Ping, GUAN Yi-Hui, XU Zhen-Sheng, JIANG Yu-Ping(1,Department of Neurology, 2pET Center, Huashan Hospital, Fudan University, Shanghai 200040; 3Shanghai Med Co, Ltd., Shanghai 200032, China ) |
| Abstract: | Aim ： To compare the radiolabeled effect of differently acquired 6-OH-BTA-0. Methods： Under the same radiolabeled conditions, nC-Triflate-CH3 was bubbled into the reactor of an automated remotely controlled synthesizer module, which contained materials in a loop. And the radiosynthesis results were purified by a small solid-phrase C18 cartridge. Results： The whole radiolabeled process took about 33 min from nCOx to [^11C]6-OH-BTA-1. Different radiocbemical purities were both between 92%,-93% and radial concentration was over 185 MBq/mL. And there were no significantly different results between these self-made chemicals. Conclusion： Differently acquired 6-OH-BTA-0 could both be available for forward PET experiments. |
| Keywords: | amyloid positron emission tomography(PET) carbon-11 6-OH-BTA-0 |
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