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| 可显影碘化油-氟尿嘧啶聚乳酸微球的研制 | |
| 引用本文： | 王新霞,张丽,周闺臣,张国庆,鲁莹,钟延强,钟延强.可显影碘化油-氟尿嘧啶聚乳酸微球的研制[J].第二军医大学学报,2010,31(10):1100-1103. |
| 作者姓名： | 王新霞 张丽 周闺臣 张国庆 鲁莹 钟延强 钟延强 |
| 作者单位： | 1. 第二军医大学东方肝胆外科医院药材科,上海,200438 2. 解放军71352部队医院药房,安阳,455000 3. 第二军医大学药学院药剂学教研室,上海,200433 |
| 摘 要： | 目的制备用于肝动脉栓塞的可显影碘化油-氟尿嘧啶(iodized oil-5-fluorouracil,iodized oil-5-Fu)聚乳酸(polylactide acid,PLA)微球。方法选择具有良好生物相容性及生物可降解性的聚乳酸为载体,加入阳性造影剂碘化油,采用复乳法制备可显影碘化油-氟尿嘧啶聚乳酸微球。以外观、粒径、载药量、包封率为考察指标,采用正交设计确定可显影碘化油-氟尿嘧啶聚乳酸微球的制备工艺。结果显微镜下微球球形圆整,粒径分布均匀,扫描电镜下微球表面有孔,平均粒径约100μm;载药量(10.78%±0.14%),包封率(63.34%±0.545%),微球显影效果好。结论以可生物降解的PLA材料可制备显影效果好的氟尿嘧啶微球,并且微球具有一定的缓释作用。 |
| 关 键 词： | 氟尿嘧啶 聚乳酸 碘化油 微球体 复乳法 |
| 收稿时间： | 2010/3/12 0:00:00 |
| 修稿时间： | 2010/9/13 0:00:00 |
Preparation of visualized iodized oil-5-fluorouracil loaded polylactic acid microspheres |
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| WANG Xin-xi,ZHANG Li,ZHOU Gui-chen,ZHANG Guo-qing,LU Ying,ZHONG Yan-qiang and ZHONG Yan-qiang.Preparation of visualized iodized oil-5-fluorouracil loaded polylactic acid microspheres[J].Academic Journal of Second Military Medical University,2010,31(10):1100-1103. | |
| Authors: | WANG Xin-xi ZHANG Li ZHOU Gui-chen ZHANG Guo-qing LU Ying ZHONG Yan-qiang and ZHONG Yan-qiang |
| Institution: | WANG Xin-xia1,ZHANG Li 2,ZHOU Gui-chen3,ZHANG Guo-qing1,LU Ying3,ZHONG Yan-qiang3 1.Department of Pharmacy,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China 2.Department of Pharmacy,Hospital of No.71325Troop,Anyang 455000,Henan,China 3.Department of Pharmacy,School of Pharmacy,Shanghai 200433,China |
| Abstract: | Objective To prepare visualized iodized oil-5-fluorouracil loaded polylactic acid(PLA)micropheres for hepatic artery embolism treatment.Methods Biocompatible and biodegradable material PLA was used as vector and iodized oil was used as positive contrast agent to prepare 5-fluorouracil loaded microspheres using double emulsion method.The preparation technology of the microspheres was developed through optimization of appearance,size distribution,drug loading, and encapsulation efficiency by orthogonal-design... |
| Keywords: | fluorouracil polylactic acid iodized oil microspheres double emulsion method |
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