| 中枢神经系统免疫性疾病单细胞组学研究进展 |
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| 引用本文： | 李志彬,程希,邱伟.中枢神经系统免疫性疾病单细胞组学研究进展[J].中国现代神经疾病杂志,2022(1):8-16. |
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| 作者姓名： | 李志彬 程希 邱伟 |
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| 作者单位： | 中山大学附属第三医院神经内科 |
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| 基金项目： | 国家自然科学基金资助项目(项目编号:81771300);国家自然科学基金资助项目(项目编号:81971140);国家自然科学基金资助项目(项目编号:82101418);广东省自然科学基金资助项目(项目编号:2020A1515010053)。 |
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| 摘 要： | 中枢神经系统免疫性疾病包括多发性硬化、视神经脊髓炎谱系疾病、抗髓鞘少突胶质细胞糖蛋白抗体相关疾病和抗N-甲基·D-天冬IK酸受体脑炎等,发病机制复杂,多种中枢神经系统和外周来源细胞参与其中.单细胞组学通过一系列测序技术实现高分辨检测单个细胞水平表达谱,以解析细胞异质性及其功能表型.本文对单细胞测序技术在常见中枢神经系统...
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| 关 键 词： | 自身免疫疾病 中枢神经系统疾病 序列分析 B-淋巴细胞 T淋巴细胞 单核细胞 巨噬细胞 小神经胶质细胞 树突细胞 综述 |
Research progress of single-cell omics in central nervous system immune diseases |
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| LI Zhi-bin,CHENG Xi,QIU Wei.Research progress of single-cell omics in central nervous system immune diseases[J].Chinese Journal of Contemporary Neurology and Neurosurgery,2022(1):8-16. |
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| Authors: | LI Zhi-bin CHENG Xi QIU Wei |
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| Institution: | (Department of Neurology,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,Guangdong,China) |
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| Abstract: | Central nervous system immune diseases include multiple sclerosis(MS),neuromyelitis optica spectrum disorders(NMOSDs),myelin oligodendrocyte glycoprotein-IgG associated disorders(MOGAD)and anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis.The pathogenesis of these diseases is complex,and a variety of central nervous system and peripheral cells are involved.Single-cell omics has achieved high-resolution detection of the expression profile at the level of single-cell through a series of sequencing techniques to analyze cell heterogeneity and functional phenotype.This review will summarize the single cell sequencing(SCS)and its applications in the above-mentioned diseases. |
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| Keywords: | Autoimmune diseases Central nervous system diseases Sequence analysis B-lymphocytes T-lymphocytes Monocytes Macrophages Microglia Dendritic cells Review |
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