从国家自然科学基金资助项目浅谈中医药在恶性肿瘤治疗中的增效减毒作用研究现状

该文通过对近十年国家自然科学基金中医药领域恶性肿瘤治疗中医药增效、减毒资助项目的 回顾性分析,系统梳理和总结中医药在协同增效、减少毒副作用方面的主要研究内容与热点.分析发现,中医药增效作用主要包括改善分子靶向药物耐药、改善多药耐药、逆转化疗耐药、协同增效及放疗增敏等方面,而在减毒方面的作用主要体现在减轻放、化疗副作用....

Research status on efficacy enhancement and toxicity reduction of Chinese medicine in treatment of malignant tumors:a review of projects supported by National Natural Science Foundation of China

Through a retrospective analysis of the projects supported by the National Natural Science Foundation of China in the past ten years in the field of Chinese medicine for the treatment of malignant tumors,this article systematically summarized the main research contents and hotspots of Chinese medicine in efficacy enhancement and toxicity reduction.The efficacy enhancement of Chinese medicine mainly included the mitigation of molecule-targeted drug resistance,multidrug resistance,and chemotherapy resistance,synergistic efficacy enhancement,and radiotherapy sensitization.The toxicity reduction is mainly reflected in the alleviation of the side effects of radiotherapy and chemotherapy.In addition,Chinese medicine has advantages in reducing serious adverse reactions of malignant tumors,providing more options for the adjuvant treatment of tumors.