| 间充质干细胞外泌体在创伤修复再生中作用的研究进展 |
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| 引用本文： | 沈志明,袁磊,卢毅,史宏灿.间充质干细胞外泌体在创伤修复再生中作用的研究进展[J].中华创伤杂志,2022(2):182-186. |
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| 作者姓名： | 沈志明 袁磊 卢毅 史宏灿 |
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| 作者单位： | 扬州大学临床医学院;扬州大学转化医学研究院;江苏省中西医结合老年病防治重点实验室 |
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| 基金项目： | 国家自然科学基金(82070020,81770018);江苏省研究生科研创新计划(KYCX21_3287)。 |
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| 摘 要： | 间充质干细胞（MSCs）外泌体能够通过旁分泌作用，发挥类似干细胞的促进组织器官修复再生的功能，避免了直接移植MSCs的风险，如致瘤、伦理、免疫排斥反应等。MSCs外泌体参与细胞通讯，维持微环境的稳态，促进细胞的增殖、迁移及细胞外基质的修复再生，且能够在不同物种之间传递，却不会引起明显的免疫反应，在组织器官的修复与再生方...
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| 关 键 词： | 间充质干细胞 外泌体 伤口愈合 再生 |
Research progress in role of exosomes derived from mesenchymal stem cells in wound healing and regeneration |
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| Shen Zhiming,Yuan Lei,Lu Yi,Shi Hongcan.Research progress in role of exosomes derived from mesenchymal stem cells in wound healing and regeneration[J].Chinese Journal of Traumatology,2022(2):182-186. |
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| Authors: | Shen Zhiming Yuan Lei Lu Yi Shi Hongcan |
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| Institution: | (Clinical Medical College,Yangzhou University,Yangzhou 225001,China;Institute of Translational Medicine,Yangzhou University,Yangzhou 225001,China;Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases,Yangzhou 225001,China) |
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| Abstract: | Exosomes derived from mesenchymal stem cells(MSCs)play a similar role of stem cells in promoting healing and regeneration of tissue and organ through paracrine,which avoids the risks of direct transplantation of mesenchymal stem cells such as tumorigenic,ethics,immune rejection,et al.Exosomes derived from MSCs that are able to participate in intercellular communication,maintain homeostasis of microenvironment,promote cell proliferation and migration,repair extracellular matrix,and transmit between different species without causing obvious immune response,exhibiting great potential in healing and regeneration of tissue and organ.The authors review the characteristics,extraction and identification of exosomes derived from MSCs and their application in the repair and regeneration of spinal cord,skin,bone,tendons,nerves and other tissues,hoping to provide a reference for clinical application of exosomes derived from MSCs in tissue and organ repair. |
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| Keywords: | Mesenchymal stem cells Exosomes Wound healing Regeneration |
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