牙髓干细胞修复周围神经损伤的研究进展

周围神经损伤(peripheral nerve injury,PNI)严重影响患者的生命质量及身心健康,并且损伤后的修复在临床上仍面临巨大挑战,PNI与再生修复研究是当今各相关学科研究的热点问题。细胞疗法在组织再生与修复中具有不可替代的作用。施万细胞是周围神经修复的理想细胞,但来源有限等缺点限制了其临床应用。牙髓干细胞来源于神经嵴,为神经再生提供了新的细胞来源。本文就牙髓干细胞修复PNI的研究现状进行综述。

Research progress of dental pulp stem cells for peripheral nerve injury repair

Peripheral nerve injuries are mainly related to severe trauma,fracture and tumor surgery,leading to reduced quality of life and impaired physical and mental health.The repair of peripheral nerve still faces great challenges in clinic,and the research on the regeneration and repair of peripheral nerve has become a hot issue in related disciplines.Cell therapy plays an irreplaceable role in tissue regeneration and repair.Schwann cells are ideal cells for peripheral nerve repair,but their limited sources inhibit the clinical application.Dental pulp stem cells are derived from neural crest,which provides a new cell source for nerve regeneration.The purpose of this article is to review the research progress of dental pulp stem cells for peripheral nerve repair.