| 三七总皂苷壳聚糖纳米粒的制备与肠吸收特性研究 |
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| 引用本文： | 徐鹏飞,张锐,关志宇,李思慧,周冬艳,姜晟,范瑾慧,徐彭,朱卫丰.三七总皂苷壳聚糖纳米粒的制备与肠吸收特性研究[J].中国中药杂志,2022(1):95-102. |
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| 作者姓名： | 徐鹏飞 张锐 关志宇 李思慧 周冬艳 姜晟 范瑾慧 徐彭 朱卫丰 |
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| 作者单位： | 江西中医药大学药学院 |
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| 基金项目： | 国家“重大新药创制”科技重大专项(2018ZX09721002-008);国家重点研发计划中医药现代化研究重点专项(2017YFC1702904);江西省中医药管理局科技计划项目(2020B0366);江西省博士后研究人员科研项目(2020KY51)。 |
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| 摘 要： | 该实验采用自组装法制备及表征三七总皂苷壳聚糖纳米粒(Panax notoginseng saponins chitosan nanoparticles,PNS-NPs),对其外观、粒径、包封率、载药量、多分散指数(PDI)、Zeta电位、微观结构等进行表征.所制得PNS-NPs形态结构完整,平均粒径为(209±0.25...
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| 关 键 词： | 三七总皂苷 壳聚糖 口服纳米粒 表征 肠吸收 |
Preparation and intestinal absorption of Panax notoginseng saponins chitosan nanoparticles |
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| XU Peng-fei,ZHANG Rui,GUAN Zhi-yu,LI Si-hui,ZHOU Dong-yan,JIANG Sheng,FAN Jin-hui,XU Peng,ZHU Wei-feng.Preparation and intestinal absorption of Panax notoginseng saponins chitosan nanoparticles[J].China Journal of Chinese Materia Medica,2022(1):95-102. |
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| Authors: | XU Peng-fei ZHANG Rui GUAN Zhi-yu LI Si-hui ZHOU Dong-yan JIANG Sheng FAN Jin-hui XU Peng ZHU Wei-feng |
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| Institution: | (School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China) |
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| Abstract: | In this experiment,Panax notoginseng saponins chitosan nanoparticles(PNS-NPs)were prepared by self-assembly and their appearance,particle size,encapsulation efficiency,drug loading,polydispersity index(PDI),Zeta potential,and microstructure were characterized.The prepared PNS-NPs were intact in structure,with an average particle size of(209±0.258)nm,encapsulation efficiency of 42.34%±0.28%,a drug loading of 37.63%±0.85%,and a Zeta potential of(39.8±3.122)mV.The intestinal absorption of PNS-NPs in rats was further studied.The established HPLC method of PNS was employed to investigate the effects of pH,perfusion rate,and different drugs(PNS raw materials,Xuesaitong Capsules,and PNS-NPs).The absorption rate constant(Ka)and apparent permeability coefficient(Papp)in the duodenum,jejunum,ileum,and colon were calculated and analyzed.As illustrated by the results,the intestinal absorption of PNS-NPs was increased in the perfusion solution at pH 6.8(P<0.05),and perfusion rate had no significant effect on the Kaand Pappof PNS-NPs.The intestinal absorption of PNS-NPs was significantly different from that of PNS raw materials and Xuesaitong Capsules(P<0.05),and the intestinal absorption of PNS-NPs was significantly improved. |
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| Keywords: | Panax notoginseng saponins(PNS) chitosan oral nanoparticles characterization intestinal absorption |
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