小儿多发性抽动症肝风内动夹痰证的临床研究

目的评定理气健脾、熄风化痰法在治疗小儿多发性抽动症肝风内动夹痰证的有效性和安全性。方法将66例符合诊断标准的多发性抽动症患儿随机分为观察组和对照组,每组各33例。试验组采用理气健脾、熄风化痰法,给予止抽片治疗;对照组给予氟哌啶醇口服治疗。两组均以12周为1疗程,共2个疗程。随访病例以研究结束6个月为期。通过耶鲁综合抽动症严重程度量表（YGTSS）观察两组治疗前后总疗效、抽动分类疗效、远期疗效、中医证候改善、不良反应与安全性。结果①试验组和对照组总有效率分别为100%、93.9%,两组中医证候改善率分别为90.9%、84.8%,两组比较差异无统计学意义（P〉0.05）。随访后,两组总有效率分别为84.0%、38.1%,远期疗效比较差异有统计学意义（P〈0.05）。②试验组运动性抽动疗效优于对照组（P〈0.05）。两组发声性抽动疗效、总疗效差异无统计学意义（P〉0.05）。③试验组无不良反应,对照组有6例出现不良反应,不良反应发生率为18.2%,两组比较差异有统计学意义（P〈0.05）。表明了中医药在治疗该病方面具有显著优势和开发应用前景。结论理气健脾、熄风化痰法是治疗小儿多发性抽动症肝风内动夹痰证的有效方法 。

Clinical Study on Liver-Wind Stirring with Phlegm in Children with Tourette's Syndrome

Objective To evaluate the efficacy and security of Regulating qi and invigorating spleen method and Stoping wind and resolving phlegm method in treating TS（Tourette＇s Syndrome）.Methods 66 patients consistent with diagnostic criteria were equally divided into the experimental group and the control group（n=33）according to the sequence of visit.Tablets of herb medicine were given to the experimental group,and Haloperidol to the control group.There were two treatment courses of 12 weeks in each group.Follow-up visit was carried on till 6 months after drug withdrawal.The changes of clinical symptoms and signs（including the frequency,intencity,complexity,co-intervention and damages of tic）were assessed by YGTSS.Results ①The total effective rate and syndrome improvement rate were 100.0% and 90.9% in experimental group,93.9% and 84.8% in control group,respectively（P〉0.05）;②The curative effects on the motor twitch in the experimental group was better than that in the control group（P〈0.05）,but had no statistical difference in total effective rate and curative effect on the sounding twitch.③No case was with adverse reaction in the experimental group,while 6 cases in the control group（18.2%）,P〈0.05.Conclusion Regulating qi and invigorating spleen method and Stoping wind and resolving phlegm method are effective for TS.