遵义市2011年疑似手足口病例实验室检测结果分析

目的对贵州省遵义市2011年1 068例疑似手足口病例进行病原学监测,为手足口病的预防和控制提供科学防控依据。方法对2011年全市1 068例疑似手足口病的咽拭子或肛拭子标本,进行实时荧光(Realtime-PCR)检测。结果检出阳性标本668例(62.55%),其中EV71阳性319例(47.75%),CoxA16阳性191例(28.59%),EV71和CoxA16两种病毒核酸阳性47例(7.04%),其他肠道病毒阳性111例(16.62%)。发病季节主要集中在4—12月,在此期间出现两次高峰(5—9月和11—12月),阳性标本中男女比例为(1.75∶1),发病年龄主要集中在1～5岁儿童(97.09%)。结论 2011年手足口病全年均有病例发生,以1～5岁儿童为主,病原主要为EV71和CoxA16,以EV71为主,较易发展为重症。

Laboratory Examination Results of Suspected Hand-Foot-and-Mouth Disease Cases in Zunyi City in 2011

Objectives To monitor the pathogens in 1 068 cases of suspected hand-foot-and-mouth disease （HFMD） in Zunyi City in 2011, to provide scientific basis for prevention and control of HFMD. Methods Throat swab or rectal swab specimens from 1 068 cases of suspected HFMD were tested by real-time fluorescence detection （Realtime-PCR）. Results A total of 688 positive cases （62.25%） in 1 068 suspected HFMD cases were detec- ted; among them, EV71 positive was detected in 319 cases （47.75%） , CoxA16 positive was detected in 191 ca- ses （28.59%） , both EV71 and CoxA16 virus nucleic acid positive was detected in 47 cases （7.04%）. Other in- testinal virus-positive was detected in 111 cases （16.62%）. The prevalent season was in April-December with two peaks （May-September and November-December）. For positive samples, the ratio of male to female was 1.75： 1, the age of onset was mainly concentrated in 1 -5 year-old children （97.09%）. Conclusion The occurrence of HFMD in 2011 was mainly in April-December in children aged 1 - 5 years, the main pathogens were EV71 and CoxA16, the prognosis of cases with EV71-based was more severe.