| 宫内苯并(a)芘暴露对胎儿癌症相关基因表达的影响 |
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| 引用本文： | 李永红,程义斌,顾珩,顾雯,金银龙.宫内苯并(a)芘暴露对胎儿癌症相关基因表达的影响[J].国外医学：卫生学分册,2012(3):101-104,111. |
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| 作者姓名： | 李永红 程义斌 顾珩 顾雯 金银龙 |
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| 作者单位： | 中国疾病预防控制中心环境与健康相关产品安全所 |
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| 基金项目： | 卫生行业科研专项项目（201002001）; “十一·五”国家科技支撑计划项目（NO.2006BAI19B01）; 国家环境与疾病监测点项目; 美国NIH Fogarty项目（5D43 TW007864-09） |
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| 摘 要： |
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| 关 键 词： | 苯并(a)芘 基因表达 宫内暴露 脐带血 Real-timePCR |
Impacts of Prenatal Benzo（a）pyrene Exposure on the Expression of Cancer-related Gene of Fetus |
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| Li Yonghong,Cheng Yibin,Gu Heng,Gu Wen,Jin Yinlong.Impacts of Prenatal Benzo（a）pyrene Exposure on the Expression of Cancer-related Gene of Fetus[J].Foreign Medical Sciences(Section of Hygiene),2012(3):101-104,111. |
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| Authors: | Li Yonghong Cheng Yibin Gu Heng Gu Wen Jin Yinlong |
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| Institution: | Li Yonghong, Cheng Yibin, Gu Heng, Gu Wen, Jin Yinlong |
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| Abstract: | Objectives To explore the impacts of prenatal benzo （a）pyrene （BaP） exposure on the expression of cancer-related gene of fetus. Methods BaP in cord serum of 20 newborns was detected by using high-performance liquid chromatography （HPLC）/fluorescence, and the mRNA of RPL27A, NUDT2 and E2F1 in cord serum was tested by real-time PCR. The relationship between BaP exposure level and gene expression was analyzed. Results The average level of BaP in 20 cord serum samples was 0. 38 ±0. 31 ug/L and the samples were grouped into 5 groups according to BaP levels. With the increase of BaP exposure, the expression of RPL27A and NUDT2 genes showed an up-regulated trend, while E2F1 gene showed a down-regulated trend. Conclusion Prenatal BaP exposure might induce a change of the expression of cancerrelated genes. |
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| Keywords: | BaP gene expression prenatal exposure cord blood real-time PCR |
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