Radiation therapy and combination of cladribine, cyclophosphamide, and prednisone as treatment of Bing-Neel syndrome: Case report and review of the literature |
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Authors: | Delgado Julio Canales Miguel Angel Garcia Beatriz Alvarez-Ferreira Javier Garcia-Grande Antonio Hernandez-Navarro Fernando |
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Affiliation: | Department of Hematology, Hospital Universitario La Paz, Madrid, Spain. |
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Abstract: | Waldenstr?m's macroglobulinemia is a low-grade lymphoma that produces monoclonal IgM. Central nervous system symptoms are frequent in Waldenstr?m's macroglobulinemia, mostly associated with blood hyperviscosity. Nevertheless, central nervous system infiltration by malignant cells (Bing-Neel syndrome) has rarely been reported. We describe the case of a 72-year-old man with Waldenstrom's macroglobulinemia and central nervous system infiltration by malignant cells with tumor formation. All similar cases reported in the literature are reviewed and the different therapeutic approaches discussed. |
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Keywords: | Waldenström Bing‐Neel radiotherapy cladribine cyclophosphamide prednisone |
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