| Basigin的分子作用机制及其在眼部的生物学功能 |
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| 引用本文： | 尹婕,李郁,王雨生.Basigin的分子作用机制及其在眼部的生物学功能[J].眼科新进展,2016,0(10):979-983. |
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| 作者姓名： | 尹婕 李郁 王雨生 |
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| 作者单位： | 210002 江苏省南京市，南京总医院眼科（尹婕）；710032 陕西省西安市，第四军医大学西京医院眼科，全军眼科研究所（尹婕，王雨生）；710032 陕西省西安市，第四军医大学细胞生物学教研室（李郁） |
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| 基金项目： | 国家自然科学基金资助(81570856、81271014、81470655)，National Natural Science Foundation of China(81570856 |
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| 摘 要： | Ｂａｓｉｇｉｎ是调节细胞活性、信号接收及免疫识别的重要分子，参与发育、微生物感染、炎症发生、营养及药物运输。Ｂａｓｉｇｉｎ的分子结构及其与分子伴侣间的同源或异源交互作用是其发挥广泛生物学功能的重要基础。Ｂａｓｉｇｉｎ与视网膜的成熟和功能发挥有重要关系，其在眼部的其他生物学功能也值得关注。本文就Ｂａｓｉｇｉｎ分子机制及眼部特异性表达的最新研究进展进行综述。
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| 关 键 词： | Basigin 视网膜 眼 发病机制 |
Molecule mechanism of Basigin and its special biological function in eye |
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| YIN Jie,LI Yu,WANG Yu-Sheng.Molecule mechanism of Basigin and its special biological function in eye[J].Recent Advances in Ophthalmology,2016,0(10):979-983. |
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| Authors: | YIN Jie LI Yu WANG Yu-Sheng |
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| Institution: | Department of Ophthatmology, Nanjing General Hospital ( YIN Jie ) , Nanjing 210002 , Jiangsu Province, China; Department of Ophthalmology , Institute of Ophthalmology of Chinese PLA ,Xijing Hospital , the Forth Military Medical University ( YIN Jie , WAWG Yu-Sheng) ,Xi ’ an 710032, .Shaanxi Province , China ; Cell Engineering Research Centre and Department of Cell Biology , the Fourth Military Medical University ( LI Yu ) , Xi ’an 710032 , Shaanxi Province , China |
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| Abstract: | Basigin , an important molecule involved in the regulation of cellular activity , signal reception and immune recognition, participates in multiple developmental processes , microbial pathologies , inflammation. nutrient and drug transporter activity. Recent research has revealed that the structure characteristics and homophilic or heterophilic molecular interactions between Basigin and its binding partners form the basis for the its pleiotrophic role. Basigin plays a critical role for full maturity and function of retina. Moreover .its other biological function in the eye also deserves special attention. This article reviews the latest research progress in the molecule mechanism of Basigin and its specific ocular expression. |
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| Keywords: | Basigin retina eye pathogenesis |
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