中文视功能相关生存质量量表-25的初步应用评价

目的研制中文视功能相关的生存质量量表-25，计算其信度和效度并应用于眼病患者中，评价量表反映眼病对患者生存质量的影响的应用效果。方法调查研究。选取美国国家眼科研究所开发的视功能相关的生存质量量表（NEI-VFQ-25），经过翻译、回译和文化调适后，形成中文量表。分别测量113例眼病患者（病例组）和38例健康体检者（对照组）视功能相关的生存质量，分析量表条目的无应答率、克朗巴赫α系数以及内容效度、结构效度、区分效度，比较病例组与对照组各维度得分之间的差异，并评估性别、年龄、文化程度及视力与量表各维度得分的相关性。采用多变量方差分析法、因子分析法以及Pearson相关分析进行数据分析。结果原量表中“开车”一项，在中文版视功能相关的生存质量量表-25中均调整为“驾车”。量表整体及各维度（除维度“眼痛”外）的克朗巴赫α系数均大于0.6，病例组和对照组的区分效度有显著的统计学意义，内容效度中各条目与其等级之间的相关系数均大于0.4，结构效度示该量表各维度及各条目均只在某一因子上有较大载荷。病例组中各眼病患者与对照组之间以及病例组中男女患者之间的量表得分差异均具有显著的统计学意义，且量表的得分与性别无明确相关性，与较好眼矫正视力及双眼矫正视力相关性高，与年龄呈负相关，且文化程度愈高者，量表得分愈高。结论中文视功能相关的生存质量量表-25的信度、效度均较高，能较全面地反映眼病患者的视力对其视功能相关的生存质量的影响。该量表得分与年龄呈负相关，并受文化水平影响，文化水平高者，量表得分亦较高。

Development and Evaluation of Chinese Version Vision-related Quality of Life Questionnaire-25

Objective To develop and test a Chinese version vision-relatde quality of life questionnaire-25.Methods In this investigtion study,the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) was translated and adapted into the Chinese version vision-related quality of life questionnaire (CVRQoL-25).The questionnaire items were completed by 113 patients with age-related cataract,hypermyopia,glaucoma,diabetic retinopathy and by a reference group (n=38).The rates of missing data,Cronbach'alpha coefficient,content validity,construct validity and discriminant validity of CVRQoL-25 were computed.The results were compared with patient demographics multivariate analysis of variance,factor analysis and Pearson correlation were used for statistical analysis.Results Based on the information from the participants,one item-"Driving" was changed to conclude driving cars and riding bicycles.At scale "Driving",the rate of missing data was very high both in patient and control groups,while all the other scales were responded to each member in the research.Cronbach'alpha coefficient for the ten scales and the total CVRQoL-25 scale were above 0.6.There was significant difference between the two groups.The content validity of all scales were above 0.4 and each scale was included in one of the major factors.The scores of CVRQoL-25 were highly correlated with visual acuity of the better eye,both eye,and with education.Conclusion With minor modifications from the English version,CVRQoL-25 can be used as one measure instrument to evaluate the vision-related quality of life of patients with eye disease.The scores of CVRQoL-25 had no significant relations with sex,and had negtive relations with age.Subjects who with higher education degree had higher scores of CVRQoL-25.