生物可降解激素缓释剂Ozurdex治疗黄斑水肿的研究进展

黄斑水肿是眼底病患者视力丧失的主要原因之一。多种因素导致血-视网膜屏障功能障碍，使血管通透性改变，血管内成分渗漏引起黄斑区水肿增厚。黄斑水肿的治疗方法多种多样，如黄斑激光光凝治疗、玻璃体内注射曲安奈德或抗血管内皮生长因子药物等都获得一定疗效。然而，它们仍各自存在局限性。近年来，生物可降解激素缓释剂为临床提供另外一种治疗选择。单独或联合应用取得了较好的临床疗效，其生物可降解及持续释放特点减少了术源性并发症，延长了药物作用时间。本文就Ｏｚｕｒｄｅｘ的结构特性，其在糖尿病视网膜病变、视网膜静脉阻塞、葡萄膜炎、玻璃体切割术后黄斑水肿患者的临床试验以及其长期疗效和安全性的相关研究进行综述。

Research progress on biodegradable hormone sustained-release agent Ozurdex for macular edema

Macular edema is one of the leading causes of vision loss among patients with fundus diseases. Many factors lead to blood retinal barrier dysfunction, which induced edema thickening of the macular region due to the change of blood vessel permeability and intravascular component leakages. Methods for macular edema are various , such as macular laser photocoagulation. intravitreal injection of triamanolone acetonide or anti-VEGF drugs effective. However , they still have some limitations. In recent years , application of biodegradable hormone sustained-release agent in clinic provides a new and effective treatment options. Separate or combined application should have achieved good clinical efficacy. The biodegradable and sustained release characteristics reduce operation complication , and prolong the time of drug action. In this article . according the characteristics of Ozurdexs structure ,its application in diabetic retinopathy , retinal vein occlusion . uveitis . macular edema of vitrectomized patients with clinical trials and long-term efficacy and safety are reviewed.