| 正常眼压性青光眼磁共振扩散张量成像技术（DTI）研究及其与临床分期的相关性 |
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| 引用本文： | 李汉林,邵毅,彭志优,周琼,裴重刚,姜建,王博.正常眼压性青光眼磁共振扩散张量成像技术（DTI）研究及其与临床分期的相关性[J].眼科新进展,2016,0(12):1129-1132. |
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| 作者姓名： | 李汉林 邵毅 彭志优 周琼 裴重刚 姜建 王博 |
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| 作者单位： | 330006 江西省南昌市，南昌大学第一附属医院眼科（李汉林，邵毅，彭志优，周琼，裴重刚）；330006 江西省南昌市，南昌大学第一附属医院影像科（姜建，王博） |
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| 基金项目： | 国家自然科学基金资助(81160118、81400372)，全国临床医药研究专项基金(L2012052)，江西省远航工程(2014022)，江西省学位与研究生教育教学改革研究项目(2015)，江西省科技平台建设项目(2013116)，江西省青年科学基金(20151BAB215016)，江西省科技支撑计划项目(20161BBG70164)，江西省教育厅科技计划项目(GJJ150242)，江西省卫计委科技计划项目(20155131)，赣江学者计划(2015)，National Natural Science Foundation of China(81160118;81400372)，Clinical Medicine Research Special-Purpose Foundation of China(L2012052)，Jiangxi Province Voyage Project(2014022)，Jiangxi Province Degree and Postgraduate Education Reform Project(2015)，Science and Technology Platform Construction Project of Jiangxi Province(2013116)，Youth Science Foundation of Jiangxi Province(20151BAB215016)，Technology and Science Foundation of Jiangxi Province(20161BBG70164)，Education Department Scientific Research Foundation(GJJ150242)，Health Development Planning Commission Science Foundation of Jiangxi Province(20155131)，Scholor Project of Ganjiang River(2015) |
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| 摘 要： | 目的 使用磁共振扩散张量成像技术（ｄｉｆｆｕｓｉｏｎｔｅｎｓｏｒｉｍａｇｉｎｇ，ＤＴＩ）研究正常眼压性青光眼（ｎｏｒｍａｌｔｅｎｓｉｏｎｇｌａｕｃｏｍａ，ＮＴＧ）患者视路的改变，探讨其与ＮＴＧ临床分期的相关性。方法 对３０例（６０眼）ＮＴＧ患者（ＮＴＧ组）和３０例（６０眼）健康志愿者（对照组）进行了前瞻性研究。ＮＴＧ临床分期使用Ｈｏｄａｐｐ-Ａｎｄｅｒｓｏｎ-ｐａｒｒｉｓｈ（ＨＡＰ）系统进行分类。所有受试者均进行磁共振ＤＴＩ扫描检测，利用软件处理定量获取视神经、视交叉、视束的各向异性分数（ｆｒａｃｔｉｏｎａｌａｎｉｓｏｔｒｏｐｙ，ＦＡ）、平均扩散系数（ａｖｅｒａｇｅｄｉｆｆｕｓｉｏｎｃｏｅｆｆｉｃｉｅｎｔ，ＡＤＣ），对比分析ＮＴＧ组与对照组视路改变区域，并检验ＮＴＧ组视路改变程度与临床分期的相关性。结果 与对照组相比，ＮＴＧ组视神经、视交叉及视束的ＦＡ值均明显降低，ＡＤＣ值均明显升高（均为Ｐ＜０．００１）；ＮＴＧ组两侧视神经、视交叉、视束的平均ＦＡ值和ＡＤＣ值均与ＮＴＧ临床分期具有相关性，其中视神经的ＦＡ值与ＮＴＧ临床分期相关性最强（ｒ＝０．７５２，Ｐ＜０．００１），而视束的ＡＤＣ值与ＮＴＧ临床分期相关性最弱（ｒ＝－０．３３１，Ｐ＜０．００１）。结论 ＤＴＩ有望成为临床诊断ＮＴＧ的可能补充手段。
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| 关 键 词： | 正常眼压性青光眼 磁共振扩散张量成像技术 临床分期 |
Study and correlative analysis between DTI parameters and clinical stages in normal tension glaucoma |
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| LI Han-Lin,SHAO Yi,PENG Zhi-You,ZHOU Qiong,PEI Chong-Gang,JIANG Jian,WANG Bo.Study and correlative analysis between DTI parameters and clinical stages in normal tension glaucoma[J].Recent Advances in Ophthalmology,2016,0(12):1129-1132. |
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| Authors: | LI Han-Lin SHAO Yi PENG Zhi-You ZHOU Qiong PEI Chong-Gang JIANG Jian WANG Bo |
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| Institution: | Department of Ophthalmology, the First Affiliated Hospital of Nanchang University ( LI Han-Lin, SHAO Yi, PENG Zhi-You, ZHOU Qiong, PEI Chong-Gang) , Nanchang 330006 ,Jiangxi Province, China; the Depanment of Radiology,the First Affiliated Hospital of Nanchang University ( JIANG Jian, WANG Bo ) , Nanchang 330006, Jiangxi Province, China |
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| Abstract: | Objective To study the changes of optic pathway in normal tension glaucoma ( NTG) by using diffusion tensor imaging ( DTI) ,and discuss the correlation between the DTI-derived parameters and NTG clinical stages. Methods Thirty cases of NTG patients and 30 cases of healthy control volunteers were prospectively studied. NTG clinical stages were classified by using HodappAnderson-parrish ( HAP) system. All subjects underwent 3. OT MRI-DTI scan test to obtain the fractional anisotropy ( FA) value and average diffusion coefficient ( ADC) value of the optic nerve,optic chiasm and optic tract by using quantitative software process. The visual pathway change region between NTG group and control group was compared,and the correlation between the changes of visual pathway and degree of clinical staging in the NTG group was tested. Results Compared with the control group,FA values of optic nerve,optic chiasm and optic tract in the NTG group showed the significant decrease,while the ADC values were significantly increased ( all P < 0. 001) ; FA and ADC values of the bilateral optic nerve,optic chiasm and optic tract in the NTG group were correlated with NTG clinical stages. FA value of optic nerve in the NTG group had the strongest correlation with NTG clinical stages ( r = 0. 752,P < 0. 001) ,while ADC value of optic tract in the NTG group had the weakest correlation with NTG clinical stages (r = - 0. 331,P < 0. 001). Conclusion DTI can be used as a potential norunvasive manner for clinically diagnosing NTG. |
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| Keywords: | normal tension glaucoma diffusion tensor imaging clinical stages |
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