| 米诺环素对糖尿病视网膜病变的作用机制研究进展 |
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| 引用本文： | 谢汝欣,黄敏丽. 米诺环素对糖尿病视网膜病变的作用机制研究进展[J]. 眼科新进展, 2016, 0(12): 1184-1187. DOI: 10.13389/j.cnki.rao.2016.0315 |
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| 作者姓名： | 谢汝欣 黄敏丽 |
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| 作者单位： | 530000 广西壮族自治区南宁市，广西医科大学第一附属医院眼科 |
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| 基金项目： | 广西自然科学基金资助(2014GXNSFAA1-18273)，广西教育厅高校科研项目(YB2014072)，Natural Science Foundation of Guangxi(2014GXNSFAA1-18273)，Guangxi Department of Education of Scientific Research Project(YB2014072) |
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| 摘 要： | 糖尿病视网膜病变（ｄｉａｂｅｔｉｃｒｅｔｉｎｏｐａｔｈｙ，ＤＲ）是糖尿病最常见且最严重的眼部并发症之一，现已成为２０～７４岁人群致盲的首要原因。其病理改变主要包括早期的神经细胞凋亡以及后期新生血管形成。米诺环素作为一种半合成四环素类抗生素，除了具有抗菌、抗炎症反应外还有抗新生血管、保护神经细胞的作用，越来越多的研究着重于米诺环素对ＤＲ的抑制作用，本文通过文献回顾，对米诺环素抑制ＤＲ的作用机制及研究进展进行综述，并对米诺环素在ＤＲ的研究方向进行展望。
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| 关 键 词： | 米诺环素 糖尿病视网膜病变 保护神经细胞 抗新生血管 |
Research progress on mechanism of minocycline on diabetic retinopathy |
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| XIE Ru-Xin,HUANG Min-Li. Research progress on mechanism of minocycline on diabetic retinopathy[J]. Recent Advances in Ophthalmology, 2016, 0(12): 1184-1187. DOI: 10.13389/j.cnki.rao.2016.0315 |
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| Authors: | XIE Ru-Xin HUANG Min-Li |
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| Affiliation: | Department of Ophthatmology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530000 , Guangxi Province , China |
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| Abstract: | Diabetic retinopathy (DR) is one of the most common and serious diabetic eye complications,has become the leading cause of blindness in people aged 20 years t0 74 years. Its pathological changes mainly include the early stage of apoptosis and the neovascularization in the later stage. Minocycline,as a semi-synthetic tetracycline antibiotics,in addition to having the effects of anti-bacterial,anti-inflammatory anti-angiogenesis as well as nerve cell protection,more and more research focus on its inhibitive effects on DR. This article reviews the mecharusm and research progression of minocycline on DR,and prospects the direction of nunocycline in studying DR. |
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| Keywords: | minocycline diabetic retinopathy nerve protection anti-angiogenesis |
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