外排转运蛋白在眼部给药中的研究动态

外排运转蛋白是一种广泛分布于人体全身组织器官的细胞膜转运蛋白,它可以将进入细胞内的外源性物质,包括药物等转运出细胞外,对细胞起到保护作用.近年研究表明,该蛋白亦分布于角膜、虹膜、睫状体、视网膜神经上皮和视网膜色素上皮(RPE)等眼部组织,每种转运蛋白都有其相对应的特异性底物及抑制剂.外排转运蛋白通过其对药物的外排转运功能影响不同给药途径中药物在眼内的利用和分布.深入研究外排运转蛋白药物的吸收和分布,清除时所起的作用,有助于进一步了解眼部给药的机制和设计给药方略,为临床眼部给药和给药途径的开发提供更多的科学依据.

Current advances on the efflux protein in ocular drug delivery

Efflux protein is an active transport protein family located on cell membranes of various human tissues,including ocular tissues.Efflux proteins can transport exogenous molecules out of the cells to function as a protective mechanism.Scientists have revealed these proteins in various human eye tissues,including cornea,iris and ciliary body,retina,as well as retinal pigment epithelium.Many studies have demonstrated that these efflux proteins have their own unique substrates and inhibitors.The effects of these efflux proteins and inhibitors can alter ocular pharmacokinetics as well as pharmacodynamics of a given therapeutics.Better understanding of the efflux proteins and their functions can provide scientific insight and guideline for development of optimal ocular drug delivery strategy.