普拉洛芬滴眼液不同用药时间对干眼症疗效的影响

目的　探讨普拉洛芬滴眼液不同用药时间对干眼症疗效的影响。方法　选取我院眼科门诊诊断为双眼干眼症的患者１１７例，按照随机数字表法将患者分成普拉洛芬１４ｄ组（３９例）、普拉洛芬３０ｄ组（４０例）和对照组（３８例）。普拉洛芬１４ｄ组给予１ｇ·Ｌ－１普拉洛芬滴眼液（１４ｄ）联合１ｇ·Ｌ－１玻璃酸钠滴眼液（３０ｄ）；普拉洛芬３０ｄ组给予１ｇ·Ｌ－１普拉洛芬滴眼液（３０ｄ）联合１ｇ·Ｌ－１玻璃酸钠滴眼液（３０ｄ），对照组仅给予１ｇ·Ｌ－１玻璃酸钠滴眼液（３０ｄ）。给药方法均为局部滴双眼，每次１滴，每天４次。分别于治疗前后检测３组患者的泪液分泌试验Ｉ（ＳｃｈｉｒｍｅｒＩｔｅｓｔ，ＳＩｔ）、泪膜破裂时间（ｔｅａｒｂｒｅａｋ-ｕｐｔｉｍｅ，ＢＵＴ）和角膜荧光素染色（ｃｏｒｎｅａｌｆｌｕｏｒｅｓｃｅｎｔｓｔａｉｎｉｎｇ，ＦＬ）评分。结果　治疗前３组患者人口基线特征比较差异均无统计学意义（均为Ｐ＞０．０５）。治疗后普拉洛芬１４ｄ组ＳＩｔ（７．１１±１．３６）ｍｍ和ＢＵＴ（８．４２±０．７９）ｓ均高于对照组ＳＩｔ（５．１９±０．８５）ｍｍ和ＢＵＴ（５．９２±１．２４）ｓ；ＦＬ评分（０．７３±０．７２）显著低于对照组（１．８８±０．７１），差异均有统计学意义（ｔＳＩｔ＝８．０００，Ｐ＜０．００１；ｔＢＵＴ ＝１０．８７０，Ｐ＜０．００１；ｔＦＬ＝－７．６６７，Ｐ＜０．００１）；治疗后普拉洛芬３０ｄ组ＳＩｔ（７．３８±１．０１）ｍｍ和ＢＵＴ（８．１２±１．００）ｓ均高于对照组，ＦＬ评分（０．８８±０．６８）显著低于对照组，差异均有统计学意义（ｔＳＩｔ＝９．１２５，Ｐ＜０．００１；ｔＢＵＴ＝９．５６５，Ｐ＜０．００１；ｔＦＬ ＝－６．６６７，Ｐ＜０．００１）；但治疗后普拉洛芬１４ｄ组与普拉洛芬３０ｄ组的ＳＩｔ、ＢＵＴ和ＦＬ评分差异均无统计学意义（ｔＳＩｔ＝－１．１２５，０．４＞Ｐ＞０．２；ｔＢＵＴ＝１．３０４，０．２＞Ｐ＞０．１；ｔＦＬ＝－１．０００，０．４＞Ｐ＞０．２）。结论　短期应用１ｇ·Ｌ－１普拉洛芬滴眼液治疗干眼症即可达到较好的疗效，它是辅助治疗干眼症的有效药物。

Curative effects of different medication time of pranoprofen eye drops on dry eye

Objective To discuss the curative effects of the different medication time of pranoprofen eye drops on dry eye. Methods A randomized.controlled,parallel clinical trial was conducted. A total of 117 patients with dry eyes from the outpatient department in our hospital between January and December of 2015 were randomly divided into three groups ,including pranoprofen 14 days group ( n = 39) , pranoprofen 30 days group ( n = 40 ) and control group ( n = 38 ) . The cases in pranoprofen 14 days group were treated with I g . L-l pranoprofen eye drops ( 14 days) and I g . L-1 sodium hyaluronate eye drops ( 30 days) . The cases in pranoprofen 30 days group were treated with I g . L-I pranoprofen eye drops (30 days) and I g . L-l sodium hyaluronate eye drops (30 days). The cases in control group were only treated with I g . L-l sodium hyaluronate eye drops ( 30 days). The same way of medication was one drop each time,4 times per day for each eye. A1l the patients were detected the scores of Schirmer I test ( SIt) , tear break-up time ( BUT) and corneal fluorescent staining ( FL) before and after treatment. Results The demography was compared during the three groups before the treatment, there was no statistical differences ( all P > 0. 05 ). The scores of Sit (7. 11 + 1. 36) mm and BUT ( 8. 42 + 0. 79) s in pranoprofen 14 days group were significantly higher than the scores of Sit ( 5. 19 +0. 85 ) mm and BUT ( 5. 92 + 1. 24 ) s in control group after the treatment. and the scores of FL ( 0. 73 + 0. 72 ) in pranoprofen 14 days group were significantly lower than the scores of FL( 1. 88 +0. 71 ) in control group after the treatment ( tsit = 8. 000 ,P < 0. 001 ; tBUT = 10. 870 ,P < 0. 001 ; tFL = - 7. 667 .P < 0. 001 ) . The scores of SIt ( 7. 38 + 1. 01 ) mm and BUT ( 8. 12 + 1. 00 ) s in pranoprofen 30 days group were sigruficantly higher than the scores of Sit and BUT in control group after the treatment . and the scores of FL( 0. 88 +0. 68 ) were significantly lower than the scores of FL in control group after the treatment ( tsit = 9. 125 .P < 0. 001 ; tBL-r = 9. 565 ,P < 0. 001 ; tFL = - 6. 667 .P < 0. 001) ; But the scores of Sit , BUT and FL between pranoprofen 14 days group and pranoprofen 30 days group had no significant difference after the treatment( tsit = - 1. 125 .0. 4 > P > 0. 2; tBur = 1. 304 , 0. 2 > P > 0. I ; tFL = - 1. 000 , 0. 4 > P > 0. 2) . Conclusion Short-term use of I g . L -l pranoprofen can achieve more effects for treatment of dry eye , which is an importantly assistant drug.