| 斑马鱼动物模型在眼科及视觉科学研究中的应用:历史与现状 |
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| 引用本文： | 陈雪莉,荆洋,张琪. 斑马鱼动物模型在眼科及视觉科学研究中的应用:历史与现状[J]. 中华实验眼科杂志, 2016, 0(4): 368-370. DOI: 10.3760/cma.j.issn.2095-0160.2016.04.017 |
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| 作者姓名： | 陈雪莉 荆洋 张琪 |
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| 作者单位： | 1. 上海复旦大学附属眼耳鼻喉科医院眼科;2. 02114,美国哈佛大学医学院麻省眼耳医院眼科 |
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| 摘 要： | 近年来,斑马鱼凭借其体型小、繁殖力强、生长发育快、胚胎透明等独特的生物学特性,成为人类疾病动物模型的理想选择,加之与人类眼部结构和基因的高度保守性,使斑马鱼受到眼科学和视觉科学领域工作者的关注.本文主要以斑马鱼模型在视觉研究中的文献为基础,对目前常用和新近发展的基因调控和编辑技术在这一领域的应用进行综述.
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| 关 键 词： | 斑马鱼 模型,动物 眼 遗传学 |
Application of zebrafish in ophthalmology and vision research : history and current progress |
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| Abstract: | In recent years,zebrafish has become ideal animal models of human disease with its unique characteristics,such as small body,fecundity,fast development and growth,embryo transparency,and so on.Furthermore,the structure and gene of zebrafish eye are highly conservative with human eye,which make ophthalmologists to pay close attentions to zebrafish.This review focused on the studies and applications on zebrafish embryonic development of eyes,and also the applications of currently used genetic regulation and editing techniques and tools. |
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| Keywords: | Zebrafish Model,animal Eye Genetics |
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