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| 重组人干扰素α-2a凝胶治疗单纯疱疹双盲随机对照临床研究 | |
| 引用本文： | 汪科,杨海珍,李福秋,白义杰,徐金华,朱学骏. 重组人干扰素α-2a凝胶治疗单纯疱疹双盲随机对照临床研究[J]. 中国皮肤性病学杂志, 2006, 20(12): 734-736 |
| 作者姓名： | 汪科 杨海珍 李福秋 白义杰 徐金华 朱学骏 |
| 作者单位： | 1. 北京大学第一医院皮肤性病科,北京,100034 2. 吉林大学第二医院皮肤性病科,吉林,长春,130041 3. 辽宁省人民医院皮肤性病科,辽宁,沈阳,110015 4. 复旦大学附属华山医院皮肤性病科,上海,200040 |
| 摘 要： | 目的评价重组人干扰素α-2a凝胶治疗单纯疱疹的疗效和安全性。方法采用多中心、随机双盲、平行对照法对237例单纯疱疹患者进行了为期2周的临床试验。结果完成试验者共231例,试验组和对照组分别为117例和114例,重组人干扰素α-2a凝胶在治疗第3,7,10天时的痊愈率和有效率与安慰剂比较,均优于安慰剂组,差异均具有显著性意义。结论重组人干扰素α-2a凝胶治疗单纯疱疹疗效肯定,耐受性好,安全性高。 |
| 关 键 词： | 重组人干扰素α-2a 单纯疱疹 安慰剂对照 |
| 文章编号： | 1001-7089（2006）12-0734-03 |
| 收稿时间： | 2006-08-04 |
| 修稿时间： | 2006-08-042006-09-11 |
A Double-blind Randomized Controlled Clinical Trial of Recombinant Interferon α-2a Gel Versus Placebo in Treatment of Herpes Simplex |
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| WANG Ke, YANG Hai-Zhen,LI Fu-qiu ,et al. A Double-blind Randomized Controlled Clinical Trial of Recombinant Interferon α-2a Gel Versus Placebo in Treatment of Herpes Simplex[J]. The Chinese Journal of Dermatovenereology, 2006, 20(12): 734-736 | |
| Authors: | WANG Ke YANG Hai-Zhen LI Fu-qiu et al |
| Affiliation: | Department of Dermatology, Peking University First Hospital , Beijing 100034 , China |
| Abstract: | Objective To study the efficacy and safety of recombinant interferon α-2a (rIFN-α2a) gel in the treatment of herpes simplex.Methods Clinical study was done on 237 cases of Herpes simplex for 2 weeks with a multiple-centre,randomized,double-bind,parallel trial.Results 231 cases have been studied.117 were in the test group,114 were in controlled group respectively.The results showed that there was a significant different of cure rates and effective rates between therapeutic group and control group at day 3,7,10.The improved rates between the two groups had significant statistic differences.Conclusion Recombinant interferon α-2a gel is a topical drug with good efficacy, safety and tolerability in treatment of Herpes simplex. |
| Keywords: | Recombinant Interferon α-2a Herpes simplex Versus placebo |
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