| 大剂量丙种球蛋白联合阿司匹林防治川畸病冠状动脉病变的临床研究 |
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| 引用本文： | 倪彩君. 大剂量丙种球蛋白联合阿司匹林防治川畸病冠状动脉病变的临床研究[J]. 中国初级卫生保健, 2009, 23(7): 89-90 |
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| 作者姓名： | 倪彩君 |
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| 作者单位： | 杭州市萧山区第四人民医院,杭州,311225 |
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| 摘 要： | 目的探讨大剂量丙种球蛋白联合阿司匹林防治川畸病冠状动脉病变的临床疗效。方法选取51例川畸病患儿，采用大剂量丙种球蛋白联合阿司匹林（观察组27例）和常规治疗（对照组24例），观察两组的临床疗效。结果观察组Ⅱ度以上冠状动脉扩张发生率及总发生率均低于对照组，差畀有统计学意义（P〈0．05）。观察组发热、充血及淋巴结肿大消退天数均短于对照组，差异有统计学意义（P〈O．05）。结论大剂量丙种球蛋白联合阿司匹林可减轻川崎病症状、缩短病程和预防冠状动脉病变的发生。
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| 关 键 词： | 丙种球蛋白 阿司匹林 川畸病 冠状动脉病变 |
The Clinical Study of Large Dose Gamma Globulin in Combination with Aspirin for Prevention of Coronary Disease Induced by Kawasaki Disesse |
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| NI Cai-jun. The Clinical Study of Large Dose Gamma Globulin in Combination with Aspirin for Prevention of Coronary Disease Induced by Kawasaki Disesse[J]. Chinese Primary Health Care, 2009, 23(7): 89-90 |
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| Authors: | NI Cai-jun |
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| Affiliation: | NI Cai-jun( Xiaoshan District, The Fourth People＇s Hospital, Hangzhou, Zhejiang, 311225, China) |
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| Abstract: | OBJECTIVE To discuss the clinical efficacy of large dose gamma globulin in combination with aspirin for prevention of coronary disease induced by Kawasaki disease. METHODS From June 2005 to June 2007, 71 children of Kawasaki disease were divided into observation group with 37 cases and control group with 34 cases, which treated with large dose gamma globulin in combination with aspirin and normal treatment, respectively. RESULTS Both the incidence of more than Ⅱ decree coronary arteriectasis and total incidence of coronary arteriectasis were significantly lower than control group (P<0.05). The regression days of febrile, congestion and lymphadenectasis in observation were all significandy shorter than those in control group (P<0.05). CONCLUSIONS Large dose gamma globulin in combination with aspirin treated with Kawasaki disease can efficiently ease symptom, shorten pathogenesis and prevent coronary disease. |
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| Keywords: | gamma globulin aspirin Kawasaki disease coronary disease |
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