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| 腹腔注射重组人表皮生长因子对多脏器功能障碍综合征小鼠死亡率的影响 | |
| 引用本文： | 汪倩,徐南平,邹音.腹腔注射重组人表皮生长因子对多脏器功能障碍综合征小鼠死亡率的影响[J].江西医药,2010,45(5):409-412. |
| 作者姓名： | 汪倩 徐南平 邹音 |
| 作者单位： | 1. 南昌大学研究生院医学部2007级,南昌,330006 2. 江西省儿童医院急救中心 3. 江西省儿童医院病理科 |
| 摘 要： | 目的研究重组人表皮生长因子（human recombinant epidermal growth factor,hrEGF）对硫代乙酰胺（thioacetamide,TAA）诱导的多脏器功能障碍综合征小鼠的保护作用。方法采用硫代乙酰胺造成小鼠化学性多脏器功能障碍综合征,观察重组人表皮生长因子的保护作用。结果小鼠腹腔注射重组人表皮生长因子能明显降低硫代乙酰胺所致多脏器功能障碍综合征小鼠死亡率,并可显著改善小鼠肝损伤病变程度。结论重组人表皮生长因子对硫代乙酰胺所致小鼠多脏器功能障碍综合征具有保护作用。 |
| 关 键 词： | 重组人表皮生长因子 硫代乙酰胺 多脏器功能障碍综合证 |
To discussion the mortality of intraperitoneal injection human recombinant epidermal growth factor (hrEGF) on multiple organs dysfunction syndromes (MODS) mice |
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| Wang Qian,Xu Nanping,Zou Yin.To discussion the mortality of intraperitoneal injection human recombinant epidermal growth factor (hrEGF) on multiple organs dysfunction syndromes (MODS) mice[J].Jiangxi Medical Journal,2010,45(5):409-412. | |
| Authors: | Wang Qian Xu Nanping Zou Yin |
| Institution: | .Grade 2007 graduate school of department of medicine in Nanchang university,330006,China |
| Abstract: | Objective To explore the protection effect of human recombinant epidermal growth factor（hrEGF） on multiple organs dysfunction syndromes（MODS） mice induced by thioacetamide（TAA）.Methods Multiple organs dysfunction syndromes mice model were induced by the noxious agent thioacetamide（TAA）in order to examined its potential beneficial effect in protecting.Results Mortality was reduced by hrEGF intraperitoneal injection and the change in liver histology was modified.Conclusion EGF may be a novel approach for the prevention and treatment of multiple organs dysfunction syndromes. |
| Keywords: | hrEGF TAA MODS |
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