| 肾移植术后急性体液性排斥反应的治疗 |
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| 引用本文： | HU Wei,周允冲,WU Zhao-xiang,邓杰. 肾移植术后急性体液性排斥反应的治疗[J]. 中国现代医学杂志, 2008, 18(14) |
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| 作者姓名： | HU Wei 周允冲 WU Zhao-xiang 邓杰 |
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| 作者单位： | 云南省昆明法医院,器官移植科,云南,昆明,650034 |
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| 摘 要： | 目的探讨肾移植术后急性体液性排斥反应的治疗方案。方法对12例肾移植术后的急性体液性排斥反应采用抗胸腺球蛋白（ATG，100mg／d×5d）、血浆置换（PP，1～3次）和大剂量丙种球蛋白（IVIG，每周1．0g／kg，分2～3次静脉滴注）联合治疗。结果12例患者排斥反应均逆转。1例患者并发急性肾小管坏死。抗排斥治疗期间未发生严重感染性并发症。随访12～38个月，1例患者在术后16个月因慢性排斥反应恢复血液透析，其余患者移植肾功能良好。结论ATG联合PP—WIG能有效逆转肾移植术后急性体液性排斥反应，成功率高，并发症少。
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| 关 键 词： | 肾移植 群体反应性抗体 人类白细胞抗原 |
Clinical research on renal transplantation of highly sensitized recipients |
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| HU Wei,ZHOU Yun-chong,WU Zhao-xiang,DENG Jie. Clinical research on renal transplantation of highly sensitized recipients[J]. China Journal of Modern Medicine, 2008, 18(14) |
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| Authors: | HU Wei ZHOU Yun-chong WU Zhao-xiang DENG Jie |
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| Affiliation: | Department of Organ Transplantation;Kunming Forensic Hospital;Kunming;Yunnan 650034;P.R.China |
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| Abstract: | [Objective] To explore the protocol of anti-rejection therapy of acute humoral rejection(AHR) after renal transplantation. [Methods] 12 cases of AHR after renal transplantation were treated by anti-thymocyte globulin and intravenous immunoglobulin(IVIG). [Results] All cases of rejection were reversed by ATG plus IVIG therapy without any severe infection complications. One case of acute tubunar necrosis occurred after anti-rejection treatment. After 12~38 months of follow-up, one renal graft lost its functio... |
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| Keywords: | kidney transplantation acute humoral rejection anti-thymocyte globulin intravenous immunoglobulin |
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