急慢性高黏滞血症模型动物血管内皮细胞分泌功能的变化及复方丹参滴丸干预作用研究

[目的]观察复方丹参滴丸对高黏滞血症血管内皮分泌功能的影响，探索其作用机制。[方法]复合因素(高分子右旋糖酐、肾上腺素、牛血清白蛋白)、长时间(112d)造成高黏滞血症慢性模型；1次性静脉注射高分子右旋糖酐，皮下注射肾上腺素造成急性高黏滞血症模型，分别用复方丹参滴丸进行治疗，观察血管内皮细胞分泌功能的变化及复方丹参滴丸的干预效果。[结果]1)慢性高黏滞血症模型血浆血栓素B2（TXB2)和内皮素(ET)浓度非常显著升高，而6-酮-前列腺素F1A(6-酮)浓度非常显著降低；2)急性高黏滞血症模型血管内皮分泌功能无显著变化；3)长期使用复方丹参滴丸能调整、改善血管内皮分泌功能的异常状态；4)复方丹参滴丸改善血管内皮分泌功能的即时效应不显著。[结论]长期应用复方丹参滴丸能调整、改善血管内皮分泌功能，血管内皮细胞可能是复方丹参滴丸的作用靶点之一，但本药改善血管内皮分泌功能的即时效应不显著。

Effect of compound DANSHEN dripping pill on the secretion of vascular endothelial cell in acute and chronic highperviscosity of blood in rabbits

To observe the effect of compound DANSHEN dripping pill on secretion of vascular endothelial cell in acute and chronic highperviscosity of blood and explore its mechanism. Multiplex factors (highmolecular dextran,epinephrine,bovine serum albumin)and long time(112 days)were used to produce chronic highperviscos blood symptom model; intravenous highmolecular dextran,and subcutaneous epinephrine in a sigle injection were employed acute to produce highperviscosity of blood symptom model.Treating with compound DANSHEN dripping pill the intervention on the secretion of vascular endotheliocyte was observed. 1) The plasma thromboxaneB 2 (TXB 2)and endothelin in chronic highperviscos of blood symptom model were markedly high,but 6-Keto-prostaglandin was distinctly lower;2)No change of secretion of vascular endotheliocyte in acute highperviscos blood symptom model was observed;3)Taking compound DANSHEN dripping pill for a long time could adjust and ameliorate the exceptional state of vascular endotheliocyte secretion.[Conclusion] Compound DANSHEN dripping pill has no marked shortly effect on secretion function of vascular endotheliocyte.