Effects of grape seed extract and its ethylacetate/ethanol fraction on blood glucose levels in a model of type 2 diabetes |
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| Authors: | In Koo Hwang Dae Won Kim Jun Hong Park Soon Sung Lim Ki‐Yeon Yoo Dae Young Kwon Dong‐Woo Kim Won‐Kook Moon Moo‐Ho Won |
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| Affiliation: | 1. Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151‐742, South Korea;2. Central Research Institute, Natural F & P Co. Ltd, Chuncheon 200‐160, South Korea;3. Department of Food and Animal Biotechnology, Seoul National University, Seoul 151‐741, South Korea;4. Regional Innovation Center, Hallym University, Chuncheon 200‐702, South Korea;5. Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chuncheon 200‐702, South Korea;6. Korea Food Research Institute, Bundang, Songnam 463‐746, South Korea |
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| Abstract: | The present study observed the effects of grape seed extract (GSE) and its ethylacetate (E) and ethylacetate/ethanol (EE) fractions on blood glucose levels in C57BL/KsJ‐leprdb/leprdb (db/db) mice at 4–12 weeks of age. In the GSE‐ and EE fraction‐treated db/db group, the blood glucose concentration began to be lower than that in the vehicle‐treated db/db group at 6 weeks after treatment, while the blood glucose concentration in the E fraction‐treated db/db group was similar to that in the vehicle‐treated db/db group. The glycosylated hemoglobin (HbA1c) level in the vehicle‐treated db/db groups was 9.3%, whereas HbA1c levels in the GSE‐ and EE fraction‐treated db/db group decreased significantly to 5.7% and 6.1%, respectively, at 8 weeks after treatment. However, administration of GSE and its EE fraction did not show any significant effects on body weights and food consumption in db/db mice. These results suggest that GSE and its EE fraction have a potential to decrease the blood glucose and HbA1c level, which is applicable to good healthy foods for reducing blood glucose levels. Copyright © 2009 John Wiley & Sons, Ltd. |
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| Keywords: | db/db mouse grape seed extract ethylacetate/ethanol fraction blood glucose glycosylated hemoglobin |
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