Isolation of hypoglycemic phytoconstituent from Swietenia macrophylla seeds |
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Authors: | Anup Maiti Saikat Dewanjee Ranabir Sahu |
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Affiliation: | Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India |
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Abstract: | The present study was undertaken to isolate a novel antidiabetic molecule from Swietenia macrophylla seeds. The hydroalcohol extract of Swietenia macrophylla seeds was subjected for bioassay guided isolation employing glucose utilization assay by the isolated rat hemi‐diaphragm method in vitro. One tetranortriterpenoid, swietenine, isolated from the chloroform fraction exhibited significant (p < 0.01) activity and the effect was comparable to that of human insulin (p < 0.01). Copyright © 2009 John Wiley & Sons, Ltd. |
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Keywords: | Swietenia macrophylla Meliaceae swietenine glucose utilization |
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