Ceftolozane/tazobactam for the treatment of serious Pseudomonas aeruginosa infections: a multicentre nationwide clinical experience |
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| Authors: | Matteo Bassetti Nadia Castaldo Annamaria Cattelan Cristina Mussini Elda Righi Carlo Tascini Francesco Menichetti Claudio Maria Mastroianni Mario Tumbarello Paolo Grossi Stefania Artioli Novella Carannante Ludovica Cipriani Davide Coletto Alessandro Russo Margherita Digaetano Angela Raffaella Losito Maddalena Peghin Antonio Vena |
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| Affiliation: | 1. Infectious Diseases Clinic, Department of Medicine, University of Udine and Azienda Sanitaria Universitaria Integrata, Udine, Italy;2. Infectious Diseases Unit, Department of Internal Medicine, Azienda Ospedaliera–Universitaria di Padova, Padua, Italy;3. Infectious Diseases Clinic, University of Modena and Reggio Emilia, Modena, Italy;4. First Division of Infectious Diseases, Cotugno Hospital, AORN dei Colli, Naples, Italy;5. Infectious Diseases Clinic, Nuovo Santa Chiara University Hospital, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy;6. Department of Public Health and Infectious Diseases, ‘Sapienza’ University of Rome, Rome, Italy;7. UOC Malattie Infettive, Fondazione Policlinico Universitario A. Gemelli IRCCS – Istituto Malattie Infettive, Università Cattolica del Sacro Cuore, Rome, Italy;8. Department of Infectious and Tropical Diseases, University of Insubria, Ospedale di Circolo-Fondazioni Macchi, Varese, Italy;9. Infectious Diseases and Hepatology Unit, Sant''Andrea Hospital La Spezia, La Spezia, Italy;10. National Institute for Infectious Diseases ‘Lazzaro Spallanzani’ IRCCS, Rome, Italy;11. Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain |
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| Abstract: | This study describes the largest clinical experience using ceftolozane/tazobactam (C/T) for different Pseudomonas aeruginosa infections. A retrospective study was performed at 22 hospitals in Italy (June 2016–March 2018). All adult patients treated with ≥4 days of C/T were enrolled. Successful clinical outcome was defined as complete resolution of clinical signs/symptoms related to P. aeruginosa infection and lack of microbiological evidence of infection. C/T treatment was documented in 101 patients with diverse infections, including nosocomial pneumonia (31.7%), acute bacterial skin and skin-structure infection (20.8%), complicated UTI (13.9%), complicated IAI (12.9%), bone infection (8.9%) and primary bacteraemia (5.9%). Over one-half of P. aeruginosa strains were XDR (50.5%), with 78.2% of isolates resistant to at least one carbapenem. C/T was used as first-line therapy in 39 patients (38.6%). When used as second-line or later, the most common reasons for discontinuation of previous antibiotics were in vitro resistance of P. aeruginosa and clinical failure of previous therapy. Concomitant antibiotics were reported in 35.6% of patients. C/T doses were 1.5 g q8h in 70 patients (69.3%) and 3 g q8h in 31 patients (30.7%); median duration of C/T therapy was 14 days. Overall clinical success was 83.2%. Significant lower success rates were observed in patients with sepsis or receiving continuous renal replacement therapy (CRRT). Mild adverse events were reported in only three patients. C/T demonstrated a favourable safety and tolerability profile regardless of the infection type. Clinicians should be aware of the risk of clinical failure with C/T therapy in septic patients receiving CRRT. |
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| Keywords: | Ceftolozane/tazobactam Ventilator-associated pneumonia |
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