Procyanidins extracted from the lotus seedpod ameliorate scopolamine‐induced memory impairment in mice |
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| Authors: | Jiqu Xu Shuang Rong Bijun Xie Zhida Sun Li Zhang Hailei Wu Ping Yao Yunjian Zhang Liegang Liu |
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| Affiliation: | 1. Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR China;2. MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR China;3. College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China;4. Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, PR China |
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| Abstract: | The major purpose of this study was to determine the effect of procyanidins extracted from the lotus seedpod (LSPC) on the learning and memory impairments induced by scopolamine (1 mg/kg, i.p.) in mice. The capacities of memory and learning were evaluated by the Morris water maze and the step‐down avoidance test. LSPC (50, 100, 150 mg/kg BW, p.o.) significantly reversed scopolamine‐induced learning and memory impairments in the Morris water maze test, as evaluated by shortened escape latency and swimming distance. In the step‐down avoidance test, LSPC (50, 100, 150 mg/kg BW, p.o.) treatment significantly reduced the number of errors and shortened latency compared with that of scopolamine. In addition, LSPC was also found to inhibit acetyl cholinesterase (AChE) activity. These results of this study suggest that LSPC may play a useful role in the treatment of cognitive impairment caused by AD and aging. Copyright © 2009 John Wiley & Sons, Ltd. |
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| Keywords: | procyanidins scopolamine memory Morris water maze step‐down avoidance test AChE activity |
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