Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model |
| |
Authors: | Hao Xu Dazhuo Shi Keji Chen Xiaochang M Yongli Li Liang Meng and Weimin Yuan |
| |
Institution: | (1) Division of Cardiovascular Diseases, Xiyuan Hospital, China Academy of TCM, 100091 Beijing;(2) Department of Experimental Surgery, Fuwai Cardiovascular Hospital, Chinese Academy of Medical Sciences, China |
| |
Abstract: | Objective: To study the effect of Xiongshao capsule (XSC) on vascular remodeling in porcine coronary balloon injury model.Methods: Coronary artery restenosis model was established by oversized balloon injury at mid-region of the left anterior descending
coronary artery. They were divided into 5 groups, untreated or treated with probucol, Xueguantong, low and high dose of XSC
respectively, and compared. The effect of XSC on late lumen loss resulted from vascular remodeling was evaluated by quantitative
histological method with combining histopathological analysis and coronary angiographie examination.Results: The (59 ± 20)% of late lumen loss was caused by vascular remodeling and (41 ± 20)% caused by intimai hyperplasia. Compared
with the control group, all the treatment could significantly reduce the late lumen loss after balloon injury (P<0.05 orP < 0.01 ), both low and high dose of XSC could significantly reduce the late lumen loss caused by remodeling (P<0.05 and P<0.01
respectively).Conclusion: Vascular remodeling plays an important role in late lumen stenosis formation in coronary artery after balloon injury. XSC
could significantly inhibit the pathological vascular remodeling, and thus reduce the late lumen loss and prevent the restenosis
of the injured coronary artery.
Part of a National Ninth-Five Planning Project (No. 96-9060601) |
| |
Keywords: | Xiongshao capsule angioplasty restenosis vascular remodeling |
本文献已被 万方数据 SpringerLink 等数据库收录! |
| 点击此处可从《Chinese Journal of Integrated Traditional and Western Medicine》浏览原始摘要信息 |
| 点击此处可从《Chinese Journal of Integrated Traditional and Western Medicine》下载免费的PDF全文 |