INTRAOCULAR AND INTRACRANIAL PRESSURE DURING RESPIRATORY ALKALOSIS AND ACIDOSIS |
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| Authors: | SMITH, R. B. AASS, A. A. NEMOTO, E. M. |
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| Affiliation: | Department of Anesthesiology, The University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive, San Antonio, Tx 78284, U.S.A.
Department of Anesthesiology, University of Pittsburgh School of Medicine Pittsburgh, Pa 15261, U.S.A. |
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| Abstract: | Intraocular and intracranial pressures (IOP and ICP) were measuredat four different arterial carbon dioxide tensions by directcontinuous techniques in Rhesus monkeys during anaesthesia withhalothane and nitrous oxide. Increases in IOP correlated significantlywith Paco2. ranging from 2.66 to 10.24 kPa (P<0.001). Increasesin ICP correlated significantly (P<0.001) with Paco2 between2.66 and 7.71 kPa, but plateaued thereafter. When Paco2 wasdecreased rapidly, Paco2, IOP and ICP decreased exponentiallywith similar half-times. The fast changes in IOP and ICP canprobably be explained by an alteration of intraocular and intracranialblood volumes. IOP usually remained within the normal range,even at maximum Paco2. |
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