Bcl11b is required for differentiation and survival of alphabeta T lymphocytes |
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| Authors: | Wakabayashi Yuichi Watanabe Hisami Inoue Jun Takeda Naoki Sakata Jun Mishima Yukio Hitomi Jiro Yamamoto Takashi Utsuyama Masanori Niwa Ohtsura Aizawa Shinichi Kominami Ryo |
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| Affiliation: | Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1-757, Niigata 951-8122, Japan. |
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| Abstract: | The gene Bcl11b, which encodes zinc finger proteins, and its paralog, Bcl11a, are associated with immune-system malignancies. We have generated Bcl11b-deficient mice that show a block at the CD4-CD8- double-negative stage of thymocyte development without any impairment in cells of B- or gammadelta T cell lineages. The Bcl11b-/- thymocytes showed unsuccessful recombination of V(beta) to D(beta) and lacked the pre-T cell receptor (TCR) complex on the cell surface, owing to the absence of Tcrb mRNA expression. In addition, we saw profound apoptosis in the thymus of neonatal Bcl11b-/- mice. These results suggest that Bcl11b is a key regulator of both differentiation and survival during thymocyte development. |
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