心电图PtfV1与胸部放疗期间左室舒张功能的相关性及其临床意义

目的 探讨心电图V1导联P波终末电势（PtfV1）与胸部放疗期间左室舒张功能的相关性及其临床意义。方法 检测并比较80例胸部肿瘤患者放疗前、后的心电图PtfV1和超声心动图指标:左室舒张早期流速峰值(E)与晚期流速峰值(A)比值（E/A）、E峰减速时间（EDT）、左房内径指数（LADI）、左室射血分数（LVEF）；分析心电图PtfV1与超声检查的左室舒张功能指标的相关性；胸部放疗后将所有患者以PtfV1≤-0.03 mm·s为界值分组，统计并分析两组左室舒张功能障碍的构成比。结果 ①胸部放疗后患者PtfV1和E/A显著降低，EDT、LADI显著增加（均P<0.01），LVEF无显著差异；②Pearson相关分析示PtfV1与EDT(r=-0.218，P<0.01)、LADI（r=-0.185，P<0.05）呈显著负相关；③多因素Logistic回归分析示PtfV1、EDT、E/A是左室舒张功能障碍的影响因素；④胸部放疗后左室舒张功能障碍构成比比较示:-0.03

Correlation between PtfV1 and left ventricular diastolic function during chest radiotherapy and its clinical significance

AIM To investigate the correlation between P wave terminal force in electrocardiogram lead V1(PtfV1) and left ventricular diastolic function during chest radiotherapy and its clinical value. METHODS Before and after chest radiotherapy, 80 patients who received chest radiotherapy had measurements taken of PtfV1 by ECG and left ventricular diastolic early peak velocity (E), late peak velocity (A) ratio (E/A), E wave decelerating time (EDT), left atrial dimension index (LADI), and left ventricular ejection force (LVEF) by echocardiogram. The correlation of PtfV1 and left ventricular diastolic function detected by echocardiogram was also analyzed and after chest radiotherapy, those patients were divided into two group: PtfV1≤-0.03 mm·s guroup and -0.03