2015-2019 年杭州地区献血人群HBsAg流行状况

目的了解近年来杭州地区献血人群HBsAg流行及分布状况,以便进一-步改进和完善HBV感染的预防策路。方法遵循献血者知情同意,采用ELISA法分别使用两种不同厂家的试剂检测献血后标本的HBsAg。回顾性分析2015年1月至2019年12月杭州地区无偿献血人群HBsAg阳性率,对年龄性别.献血次数等不同分布组的HBsAg阳性情况进行比较。结果共检测无偿献血者741 441人,HBsAg阳性率为0.231%。2015-2019 年HBsAg阳性率分别为0.321% .0.241% .0.251% .0.179% .0.172% ,差异有统计学意义(P<0.001)。将无偿献血人群分为18-2425-34.35-44.45--5455-60岁年龄组,各年龄组随着年龄增加献血人群比例下降,HBsAg阳性率存在差异,其中45-54岁年龄组阳性率最高(0.512%) ,差异有统计学意义(P<0.001)。男、女献血者HBsAg阳性率分别为0.271%和0.168% ;初次献血者阳性率为0.336% ,两次献血的人群阳性率为0.017%,两者差异均有统计学意义(P<0.001)。结论杭州地区无偿献血人群HBsAg阳性率低,不同年龄.性别和献血次数人群的阳性率存在差异,提高重复献血者率有利于提升血液安全。

Prevalence of HBsAg in the blood donors in Hangzhou from 2015 to 2019

Objective To understand the prevalence and distribution of HBsAg among blood donors in Hangzhou in re-cent years, so as to further improve and perfect the prevention strategy of HBV infection. Methods Informed consent of blood donors was followed, and HBsAg was detected in post-donation specimens by enzyme linked immunosorbent as-say (ELISA) using reagents from two different manufacturers, respectively. To retrospectively analyze the hepatitis Bvirus surface antigen (HBsAg) positivity rate of the voluntary blood donors in Hangzhou from January 2015 to December 2019, and compare the HBsAg positivity among groups with different ages, genders, and number of blood donations.Results A total of 741 441 cases of voluntary blood donors were tested, and the HBsAg positivity rate was 0.231%. The HBsAg positivity rates from 2015 to 2019 were 0.321%, 0.241%, 0.251%, 0.179%, and 0.172%, respectively, with sta-tistically significant diference (P<0.001). The voluntary blood donors was divided into 18-24, 25-34, 35- 44, 45-54, and 55-60 age groups, and the proportion of blood donors decreased with increasing age in each age group. There were dif-ferences in HBsAg positivity rates, and the positivity rate of 45-54 age group was the highest (0.5 12%), with statistically signifcant difference (P<0.001). The HBsAg positivity rates of male and female blood donors were 0.271% and 0. 168%,respectively. In addition, the positivity rate of fist-time donors was 0.336% and that of those who donated blood twice was 0.017%, both with satistically significant differences (P<0.001). Conclusion The HBsAg positivity rate in the vol-untary blood donors in Hangzhou is low, and there are differences in the positivity rate among people of different ages,genders and number of blood donations. Meanwhile, increasing the rate of repeat blood donation is beneficial to im-proving blood safety.