结肠癌不同治疗方式的临床疗效与应激反应观察

目的探讨结肠癌病例采用腹腔镜根治术.传统开腹术的疗效及应激反应。方法选取2018年1月至2019年1月于湖北省大冶市人民医院行传统开腹手术的48例结肠癌患者为对照组,同期选取行腹腔镜根治术的48例结肠癌患者为研究组,比较两组手术疗效.应激反应.并发症。结果研究组切口长度、术中实际出血量较对照组低,手术操作用时较对照组长,差异有极其显著的统计学意义(P<0.001);两组淋巴结清扫数比较,差异无统计学意义(P>0.05)。研究组消化功能复常用时、术后镇痛用时及住院天数明显短于对照组,术后吗啡用量明显少于对照组。差异极其显著的有统计学意义(P<0.001)。研究组并发症总发生率为8.33%。明显低于对照组的2292%,差异有统计学意义(P<0.05)。两组癌细胞转移.肿瘤复发及2年生存率比较.差异无统计学意义(P>0.05)。研究组术前应激与炎症反应指标相关数据与对照组保持一-致(P>0.05),术后 3 d除SOD外,研究组其他各指标均较对照组低,差异有极其显著的统计学意义(P0.001)。结论针对结肠癌患者施行腹腔镜根治术治疗,可获得与传统开腹相近的根治效果,同时手术创伤更小、术中实际出血量更少、患者机体应激与炎症反应更轻.并发症控制情况更佳,有利于患者快速康复。

Observation on the clinical efficacy and stress response of different treatment methods for colon cancer

Objective To investigate the efficacy and stress response of laparoscopic radical resection and traditionallaparotomy in patients with colon cancer. Methods A total of 48 patients with colon cancer who received traditional laparotomy in Daye People''s Hospital in Hubei Province from January 2018 to January 2019 were selected as the controlgroup, and 48 patients with colon cancer who received laparoscopic radical resection in the same period were selectedas the study group. Surgical efficacy, stress response, and complications were compared. Results The incision lengthmeasurement data and actual intraoperative blood loss in the study group were lower than that in the control group, andthe operation time was longer than that in the control group, and the differences were extremely statistically significant(P<0.001). There was no significant difference in the number of dissected lymph nodes between the two groups (P>0.05).The time of digestive function recovery, postoperative analgesia time and hospital stay in the study group were shorterthan that in the control group, the postoperative morphine dosage were less than that in the control group, and the differences were extremely statistically significant(P<0.001). The total complication rate in the study group was 8.33%,which was lower than that of 22.92% in the control group, and the difference was statistically significant (P<0.05). Therewere no statistically significant differences in the statistics of cancer cell metastasis, tumor recurrence, and 2-year survival rate between the two groups (P>0.05). The results of stress and inflammatory response indicators were analyzed.The preoperative relevant data in the study group were consistent with those in the control group (P>0.05). Except forSOD, the other indicators at three days after operation were lower than those in the control group, and the differencewas extremely statistically significant (P<0.001). ConclusionLaparoscopic radical resection for patients with colon cancer can obtain a similar radical effect to traditional laparotomy, with less surgical trauma, less actual intraoperativeblood loss, less stress and inflammatory response, better control of complications, which is conducive to rapid recoveryof patients.