止颤汤治疗帕金森病运动并发症的临床研究＊

目的 观察止颤汤治疗帕金森病运动并发症的临床疗效。方法 采用双盲、安慰剂平行对照临床试验设计,将100例帕金森病运动并发症患者,随机分为治疗组（50例）与对照组（50例）,两组在原有治疗方案上,治疗组加服止颤汤颗粒剂,对照组加服止颤汤颗粒安慰剂,疗程12周,每4周随访1次,比较两组帕金森病综合评分量表IV（UPDRS IV）、不自主运动评定量表（AIMS）、中医证候量表评分,评价患者帕金森病运动并发症改善情况。结果 治疗后治疗组各项评分随时间改善,UPDRSIV、UPDRSIV-A、中医证候评分从第8周起与对照组比较,差异有统计学意义（P < 0.05或P < 0.01）,AIMS肢体部分评分在12周时与对照组比较,差异有显著统计学意义（P < 0.01）;与对照组相比,治疗组中医证候疗效有明显改善（P < 0.01）。结论 止颤汤治疗帕金森病运动并发症有效。

Observation on the Clinical Effect of Zhichan Decoction in the Treatment of Motor Complication of Parkinson's Disease

Objective To observe the clinical effect of Zhichan Decoction in the treatment of motor complication of Parkinson''s disease (PD).Methods Totally 100 patients with motor complications of PD were enrolled in a double-blind, placebo-controlled parallel group clinical trial design, and were divided into a treatment group (50 cases) and control group (50 cases). On the basis of the original treatment plan, the treatment group received Zhichan Decoction granule, and the control group received Zhichan Decoction granule placebo. During the 12-week treatment course, each patient received a follow-up visit every 4 weeks. The unified PD rating scale IV (UPDRS IV), Abnormal Involuntary Movement Scale (AIMS), Traditional Chinese Medicine Syndrome Score Scale (TCMSSS) were compared. The improvement of patients with Parkinson''s disease movement complications were compared.Results After treatment, the scores of the treatment group improved over time. The scores of UPDRSIV, UPDRSIV-A, and TCM syndromes were compared with those of the control group from the 8^th week, and the differences were statistically significant (P < 0.05 or P < 0.01). The AIMS limb scores were compared with the control group at 12 weeks, and the difference was statistically significant (P < 0.01). Compared with the control group, the treatment group showed significant improvement in the efficacy of TCM syndromes (P < 0.01).Conclusion The effect of Zhichan decoction in the treatment of motor complications of PD is ideal.